Invitrogen

ELP2 Polyclonal Antibody

ELP2 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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ELP2 Antibody (PA5-104283) in IHC (P)

Immunohistochemistry analysis of paraffin-embedded ELP2 in human kidney tissue. Antigen retrieval was performed using citrate buffer. Samples were blocked with blocking buffer (1.5 hr, 22°C), incubated with ELP2 polyclonal antibody (Product # PA5-104283) using a dilution of 1:100 (1.5 hr, 22°C), followed by HRP conjugated goat anti-rabbit.

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产品信息

PA5-104283

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1:1,000

免疫组化（石蜡） (IHC (P))

1:50-1:200

免疫细胞化学 (ICC/IF)

1:100-1:500

产品规格

种属反应

Human, Mouse, Rat

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

A synthesized peptide derived from human ELP2(Accession Q6IA86), corresponding to amino acid residues K199-D249.

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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1 mg/mL

纯化类型

Affinity chromatography

保存液

PBS, pH 7.4, with 50% glycerol

内含物

0.02% sodium azide

保存条件

-20°C

运输条件

Wet ice

AB_2853594

产品详细信息

Antibody detects endogenous levels of total StIp1.

靶标信息

ELP2 regulates the ligand-dependent activation of STAT3. The protein acts as subunit of the RNA polymerase II elongator complex, which is a histone acetyltransferase component of the RNA polymerase II (Pol II) holoenzyme and is involved in transcriptional elongation. Elongator may play a role in chromatin remodeling and is involved in acetylation of histones H3 and probably H4.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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引用该产品

生物信息学

蛋白别名: elongation protein 2 homolog; Elongator complex protein 2; elongator protein 2; ELP2; SHINC-2; signal transducer and activator of transcription 3 interacting protein 1; signal transducer and activator of transcription interacting protein 1; STAT3-interacting protein 1; StIP1

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基因别名: AU023723; ELP2; Epl2; SHINC-2; STATIP1; StIP; StIP1

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UniProt ID: (Human) Q6IA86, (Mouse) Q91WG4, (Rat) Q496Z0

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Entrez Gene ID: (Human) 55250, (Mouse) 58523, (Rat) 307545

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功能

RNA polymerase II core binding transcriptional repressor activity, RNA polymerase II transcription factor binding protein kinase binding histone binding protein binding DNA binding endopeptidase activator activity

参与通路

transcription, DNA-templated regulation of transcription, DNA-templated regulation of JAK-STAT cascade transcription elongation from RNA polymerase II promoter positive regulation of endopeptidase activity proteasome assembly negative regulation of transcription from RNA polymerase II promoter regulation of transcription from RNA polymerase II promoter