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产品信息
PA5-27905
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant fragment corresponding to a region within amino acids 283 and 694 of Human ENPP1
偶联物
形式
Liquid
浓度
0.14 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7, with 1% BSA, 20% glycerol
内含物
0.025% ProClin 300
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_2545381
产品详细信息
Recommended positive controls: HepG2, A549, human liver.
Predicted reactivity: Rabbit (91%), Bovine (88%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
靶标信息
This gene is a member of the ecto-nucleotide pyrophosphatase/phosphodiesterase (ENPP) family. The encoded protein is a type II transmembrane glycoprotein comprising two identical disulfide-bonded subunits. This protein has broad specificity and cleaves a variety of substrates, including phosphodiester bonds of nucleotides and nucleotide sugars and pyrophosphate bonds of nucleotides and nucleotide sugars. This protein may function to hydrolyze nucleoside 5' triphosphates to their corresponding monophosphates and may also hydrolyze diadenosine polyphosphates. Mutations in this gene have been associated with 'idiopathic' infantile arterial calcification, ossification of the posterior longitudinal ligament of the spine (OPLL), and insulin resistance.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: alkaline phosphodiesterase 1; Alkaline phosphodiesterase I; E-NPP 1; Ectonucleotide pyrophosphatase/phosphodiesterase family member 1; HGNC:3356; Ly-41 antigen; Membrane component chromosome 6 surface marker 1; membrane component, chromosome 6, surface marker 1; NPPase; Nucleotide diphosphatase; Nucleotide pyrophosphatase; OTTHUMP00000043194; Phosphodiesterase I/nucleotide pyrophosphatase 1; plasma-cell membrane glycoprotein 1; Plasma-cell membrane glycoprotein PC-1
基因别名: ARHR2; COLED; ENPP1; M6S1; NPP1; NPPS; PC-1; PC1; PCA1; PDNP1
UniProt ID: (Human) P22413
Entrez Gene ID: (Human) 5167
nucleic acid binding
phosphodiesterase I activity
nucleotide diphosphatase activity
scavenger receptor activity
insulin receptor binding
calcium ion binding
protein binding
ATP binding
zinc ion binding
polysaccharide binding
NADH pyrophosphatase activity
protein homodimerization activity
nucleoside-triphosphate diphosphatase activity
3'-phosphoadenosine 5'-phosphosulfate binding
generation of precursor metabolites and energy
riboflavin metabolic process
phosphate-containing compound metabolic process
receptor-mediated endocytosis
immune response
nucleoside triphosphate catabolic process
negative regulation of cell growth
regulation of bone mineralization
inorganic diphosphate transport
cellular phosphate ion homeostasis
sequestering of triglyceride
biomineral tissue development
negative regulation of protein autophosphorylation
cellular response to insulin stimulus
negative regulation of fat cell differentiation
negative regulation of glycogen biosynthetic process
negative regulation of glucose import
negative regulation of insulin receptor signaling pathway
3'-phosphoadenosine 5'-phosphosulfate metabolic process
nucleic acid phosphodiester bond hydrolysis
