Search Thermo Fisher Scientific
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
产品信息
PA5-85221
产品规格
种属反应
Human,
Mouse
已发表种属
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant protein encompassing a sequence within the C-terminus region of human Autotaxin.
偶联物
形式
Liquid
浓度
0.13 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7, with 20% glycerol, 1% BSA
内含物
0.01% thimerosal
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_2792364
产品详细信息
Keep as concentrated solution.
Predicted reactivity: Mouse (93%), Rat (94%), Chicken (81%), Bovine (93%).
Positive Control: human cerebrospinal fluid, mouse brain, rat brain.
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
靶标信息
The protein encoded by this gene functions as both a phosphodiesterase, which cleaves phosphodiester bonds at the 5' end of oligonucleotides, and a phospholipase, which catalyzes production of lysophosphatidic acid (LPA) in extracellular fluids. LPA evokes growth factor-like responses including stimulation of cell proliferation and chemotaxis. This gene product stimulates the motility of tumor cells and has angiogenic properties, and its expression is upregulated in several kinds of carcinomas. The gene product is secreted and further processed to make the biologically active form. Several alternatively spliced transcript variants encoding different isoforms have been identified.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: Autotaxin; autotaxin-t; AutotaxinATX; E-NPP 2; Ectonucleotide pyrophosphatase/phosphodiesterase family member 2; Extracellular lysophospholipase D; FLJ26803; LysoPLD; phosphodiesterase I/nucleotide pyrophosphatase 2; plasma lysophospholipase D
基因别名: ATX; ATX-X; AUTOTAXIN; ENPP2; LysoPLD; NPP2; Npps2; PD-IALPHA; PDNP2
UniProt ID: (Human) Q13822, (Mouse) Q6PDE0
Entrez Gene ID: (Human) 5168, (Mouse) 18606
nucleic acid binding
phosphodiesterase I activity
nucleotide diphosphatase activity
lysophospholipase activity
scavenger receptor activity
calcium ion binding
transcription factor binding
zinc ion binding
hydrolase activity
polysaccharide binding
alkylglycerophosphoethanolamine phosphodiesterase activity
catalytic activity
metal ion binding
negative regulation of cell-matrix adhesion
lipid metabolic process
chemotaxis
immune response
metabolic process
positive regulation of cell proliferation
phospholipid catabolic process
positive regulation of epithelial cell migration
lipid catabolic process
regulation of cell migration
phosphatidylcholine catabolic process
regulation of angiogenesis
positive regulation of oligodendrocyte differentiation
positive regulation of peptidyl-tyrosine phosphorylation
positive regulation of focal adhesion assembly
cell chemotaxis
nucleic acid phosphodiester bond hydrolysis
positive regulation of substrate adhesion-dependent cell spreading
positive regulation of lamellipodium morphogenesis
phosphate-containing compound metabolic process
receptor-mediated endocytosis
movement of cell or subcellular component
G-protein coupled receptor signaling pathway
