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产品信息
H00002039-B01P
产品规格
种属反应
Human,
Rat
宿主/亚型
Mouse
/ IgG
分类
Polyclonal
类型
Antibody
抗原
EPB49 (AAH52805.1, 1 a.a. approximately 383 a.a) full-length human protein.
偶联物
形式
Liquid
浓度
0.5 mg/mL
纯化类型
Protein A
保存液
PBS, pH 7.4
内含物
no preservative
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Product may be used with Western Blot (Transfected lysate).
The Isotype of this product is composed of an IgG Mixture.
Immunogen sequence: MERLQKQPLT SPGSVSPSRD SSVPGSPSSI VAKMDNQVLG YKDLAAIPKD KAILDIERPD LMIYEPHFTY SLLEHVELPR SRERSLSPKS TSPPPSPEVW ADSRSPGIIS QASAPRTTGT PRTSLPHFHH PETSRPDSNI YKKPPIYKQR ESVGGSPQTK HLIEDLIIES SKFPAAQPPD PNQPAKIETD YWPCPPSLAV VETEWRKRKA SRRGAEEEEE EEDDDSGEEM KALRERQREE LSKVTSNLGK MILKEEMEKS LPIRRKTRSL PDRTPFHTSL HQGTSKSSSL PAYGRTTLSR LQSTEFSPSG SETGSPGLQI YPYEMLVVTN KGRTKLPPGV DRMRLERHLS AEDFSRVFAM SPEEFGKLAL WKRNELKKKA SLF
靶标信息
The protein encoded by this gene is an actin binding and bundling protein that plays a structural role in erythrocytes, by stabilizing and attaching the spectrin/actin cytoskeleton to the erythrocyte membrane in a phosphorylation-dependent manner. This protein contains a core domain in the N-terminus, and a headpiece domain in the C-terminus that binds F-actin. When purified from erythrocytes, this protein exists as a trimer composed of two 48 kDa polypeptides and a 52 kDa polypeptide. The different subunits arise from alternative splicing in the 3' coding region, where the headpiece domain is located. Disruption of this gene has been correlated with the autosomal dominant Marie Unna hereditary hypotrichosis disease, while loss of heterozygosity of this gene is thought to play a role in prostate cancer progression. Alternative splicing results in multiple transcript variants encoding different isoforms.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Dematin; Dematin actin-binding protein; Erythrocyte membrane protein band 4.9; erythrocyte membrane protein band 4.9 (dematin); erythrocyte protein band 4.9
基因别名: DMT; DMTN; Epb4.9; EPB49
UniProt ID: (Human) Q08495
Entrez Gene ID: (Human) 2039, (Rat) 361069
protein complex assembly
cytoskeleton organization
regulation of cell shape
regulation of lamellipodium assembly
positive regulation of fibroblast migration
negative regulation of peptidyl-threonine phosphorylation
negative regulation of cell-substrate adhesion
actin cytoskeleton organization
positive regulation of blood coagulation
regulation of actin cytoskeleton organization
negative regulation of peptidyl-serine phosphorylation
calcium-mediated signaling using intracellular calcium source
calcium-mediated signaling using extracellular calcium source
erythrocyte development
negative regulation of peptidyl-tyrosine phosphorylation
actin filament bundle assembly
regulation of filopodium assembly
actin filament capping
negative regulation of focal adhesion assembly
transmembrane transport
protein secretion by platelet
cellular response to calcium ion
cellular response to cAMP
positive regulation of wound healing
negative regulation of protein targeting to membrane
actin filament reorganization
negative regulation of substrate adhesion-dependent cell spreading
positive regulation of substrate adhesion-dependent cell spreading
positive regulation of platelet aggregation
positive regulation of integrin-mediated signaling pathway
