Invitrogen

EPC1 Polyclonal Antibody

EPC1 Antibody in Immunocytochemistry (ICC/IF)

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EPC1 Antibody (PA5-140053) in ICC/IF

Immunofluorecent analysis of EPC1 in human cell line U-2 OS using EPC1 Polyclonal Antibody (Product # PA5-140053). Staining shows localization to nucleoplasm and vesicles.

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产品信息

PA5-140053

应用

建议稀释比

已发表文章

免疫细胞化学 (ICC/IF)

0.25-2 µg/mL

产品规格

种属反应

Human

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

Recombinant protein corresponding to Human EPC1. Recombinant protein control fragment (Product #RP-108787).

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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

0.2 mg/mL

纯化类型

Antigen affinity chromatography

保存液

PBS, pH 7.2, with 40% glycerol

内含物

0.02% sodium azide

保存条件

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

运输条件

Wet ice

RRID

AB_2927055

产品详细信息

Gently mix before use. Optimal concentrations and conditions for each application should be determined by the user.

Immunogen sequence: DYDSVFHHLD LEMLSSPQHS PVNQFANTSE TNTSDKSFSK DLSQILVNIK SCRWRHFRPR TPSLHDSDND ELSCRKLYRS INRTGTAQPG TQTCSTSTQS KSSSGSAHFA FTAEQYQQHQ QQLALMQKQQ LAQIQQQQA

靶标信息

EPC1 is a component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when directly recruited to sites of DNA damage.

仅用于科研。不用于诊断过程。未经明确授权不得转售。