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产品信息
MA5-33375
应用
建议稀释比
已发表文章
产品规格
种属反应
Human
宿主/亚型
Rat
/ IgG1
分类
Monoclonal
类型
Antibody
克隆号
RCR-252
抗原
Human EPCR-positive RE-1 cells
偶联物
形式
Liquid
浓度
100 µg/mL
纯化类型
Protein G
保存液
PBS with 0.1% BSA
内含物
no preservative
保存条件
4° C
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2815513
产品详细信息
Product is supplied at 1 mL (100 µL/mL).
Application Notes: Flow cytometry- This antibody stains the extracellular domain of human EPCR. RE-1 cells were used as a positive control and N1 cells were used as a negative control. Western blot - A non-reduced sample treatment was used. The observed band size is 50 kDa. Functional Assay: This antiboyd functions as blocking antbody. It ablates APC binding to EPCR and blocks APC-mediated signaling. The antibody was functionally tested by pretreatment of cells with 10-25 µg/ml RCR-252. Positive control: RE-1 (rat 3Y1 fibroblasts stably transfected with human EPCR); Negative control: N1 cells.
靶标信息
The protein encoded by this gene is a receptor for activated protein C, a serine protease activated by and involved in the blood coagulation pathway. The encoded protein is an N-glycosylated type I membrane protein that enhances the activation of protein C. Mutations in this gene have been associated with venous thromboembolism and myocardial infarction, as well as with late fetal loss during pregnancy.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Activated protein C receptor; APC receptor; bA42O4.2; CD201; CD201 antigen; cell cycle, centrosome-associated protein; centrocyclin; Endothelial cell protein C receptor; Endothelial protein C receptor; protein C receptor, endothelial
基因别名: CCCA; CCD41; EPCR; PROCR
UniProt ID: (Human) Q96CB3
Entrez Gene ID: (Human) 10544
