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EPS15 Antibody (IHC-00337) in IHC (P)
Detection of human EPS15 by IHC-IF. Sample: FFPE section of human testicular seminoma. Antibody: Affinity purified rabbit anti-EPS15 (Product # IHC-00337) used at a dilution of 1:100. Detection: Red-fluorescent goat anti-rabbit IgG highly cross-adsorbed Antibody Hilyte Plus™ 555 used at a dilution of 1:100.
产品信息
IHC-00337
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Region between residue 575 and 625 of human epidermal growth factor receptor pathway substrate 15.
偶联物
形式
Liquid
浓度
0.10 mg/mL
纯化类型
Antigen affinity chromatography
保存液
TBS, pH 7.0 to 8.0, with 0.1% BSA
内含物
0.09% sodium azide
保存条件
4° C
运输条件
Wet ice
产品详细信息
The recommended shelf life for this product is 1 year from date of receipt.
Based on 100% sequence identity, this antibody is predicted to react with Orangutan, Monkey, Chimpanzee, Northern white-cheeked gibbon and Crab-eating macaque
靶标信息
EPS15 is a ubiquitously expressed protein that is involved in cell growth regulation and may be involved in the regulation of mitogenic signals and control of cell proliferation. Phosphorylation of EPS15 on Tyrosine 849 upon DNA damage is involved in the internalization of EGFR. A chromosomal aberration involving EPS15 is also found in acute leukemias, resulting in a rogue activator protein.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: AF-1p protein; ALL1 fused gene from chromosome 1; Epidermal growth factor receptor substrate 15; Protein AF-1p; Protein Eps15
基因别名: AF-1P; AF1P; EPS15; MLLT5
UniProt ID: (Human) P42566
Entrez Gene ID: (Human) 2060
Golgi to endosome transport
epidermal growth factor receptor signaling pathway
cell proliferation
protein transport
vesicle organization
receptor-mediated endocytosis of virus by host cell
endocytic recycling
negative regulation of epidermal growth factor receptor signaling pathway
viral entry into host cell
clathrin coat assembly
cell-cell adhesion
