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EPS8L1 Antibody (PA5-101217) in ICC/IF
Immunocytochemistry analysis of EPS8L1 in Hela cells. The samples were fixed with PFA and permeabilized in 0.1% Triton X-100, then blocked in 10% serum for 45 minutes at 25°C. Samples were incubated with EPS8L1 polyclonal antibody (Product # PA5-101217) and mouse anti-beta tubulin antibody for 1 hour at 37°C. An AlexaFluor594 conjugated goat anti-rabbit IgG(H+L) (Red) and an AlexaFluor488 conjugated goat anti-mouse IgG(H+L) (Green) were used as the secondary antibodies. The nuclear counter stain is DAPI (blue).
产品信息
PA5-101217
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthesized peptide derived from human EPS8L1(Accession Q8TE68), corresponding to amino acid residues Y416-L466.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Affinity chromatography
保存液
PBS, pH 7.4, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice
RRID
AB_2850658
产品详细信息
Antibody detects endogenous levels of total ES8L1.
靶标信息
Eps8L1 (EPS8-like 1), also known as DRC3 or EPS8R1, is a 723 amino acid protein that localizes to the cytoplasm and belongs to the Eps8 (epidermal growth factor receptor pathway substrate 8) family. Expressed in placental tissue, Eps8L1 functions to stimulate the guanine exchange activity of Sos 1 (son of sevenless homolog 1), a protein that promotes the exchange of Ras-bound GDP for GTP. Additionally, Eps8L1 is thought to associate with Actin and, via this association, may play a role in membrane ruffling and remodeling of the Actin cytoskeleton. Through its ability to regulate protein activation and cytoskeleton dynamics, Eps8L1 may participate in cell growth and differentiation events within the cell. Eps8L1 contains one SH3 domain and is expressed as four isoforms due to alternative splicing events.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Epidermal growth factor receptor kinase substrate 8-like protein 1; Epidermal growth factor receptor pathway substrate 8-related protein 1; EPS8-like 1; EPS8-like protein 1; EPS8-related protein 1
基因别名: 2310051G19Rik; 4632407K17Rik; AW060268; DRC3; EPS8L1; EPS8R1; PP10566
UniProt ID: (Human) Q8TE68, (Mouse) Q8R5F8
Entrez Gene ID: (Human) 54869, (Mouse) 67425
