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This target displays homology in the following species: Dog: 93%; Horse: 86%; Human: 100%; Pig: 79%; Rabbit: 79%; Rat: 79%
This gene encodes a WD repeat protein, which interacts with Cockayne syndrome type B (CSB) protein and with p44 protein, a subunit of the RNA polymerase II transcription factor IIH. Mutations in this gene have been identified in patients with hereditary disease Cockayne syndrome (CS). CS cells are abnormally sensitive to ultraviolet radiation and are defective in the repair of transcriptionally active genes.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: Cockayne syndrome WD repeat protein CSA; Cockayne syndrome WD-repeat protein CSA; DNA excision repair protein ERCC-8; excision repair cross-complementation group 8; excision repair cross-complementing rodent repair deficiency complementation group 8; excision repair cross-complementing rodent repair deficiency, complementation group 8
基因别名: CKN1; CSA; ERCC8; UVSS2
UniProt ID: (Human) Q13216
Entrez Gene ID: (Human) 1161