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产品信息
PA5-17141
产品规格
种属反应
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic peptide corresponding to the sequence of mouse THEX1
偶联物
形式
Liquid
纯化类型
Antigen affinity chromatography
保存液
0.01M HEPES, pH 7.5, with 0.15M NaCl, 100µg/mL BSA, 50% glycerol
内含物
no preservative
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_10979916
产品详细信息
It is not recommended to aliquot this antibody.
靶标信息
RNA exonuclease that binds to the 3'-end of histone mRNAs and degrades them, suggesting that it plays an essential role in histone mRNA decay after replication. A 2' and 3'-hydroxyl groups at the last nucleotide of the histone 3'-end is required for efficient degradation of RNA substrates. Also able to degrade the 3'-overhangs of short interfering RNAs (siRNAs) in vitro, suggesting a possible role as regulator of RNA interference (RNAi). Requires for binding the 5'-ACCCA-3' sequence present in stem-loop structure. Able to bind other mRNAs. Required for 5.8S rRNA 3'-end processing. Also binds to 5.8s ribosomal RNA. Binds with high affinity to the stem-loop structure of replication-dependent histone pre-mRNAs.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: 3 ' exoribonuclease; 3' exoribonuclease; 3'-5' exonuclease ERI1; 3'-5' exoribonuclease 1; enhanced RNAi protein 1; Eri-1 homolog; histone mRNA 3' end-specific exonuclease; Histone mRNA 3'-exonuclease 1; protei; three prime histone mRNA exonuclease 1
基因别名: 3'exo; 3'hexo; 3110010F15Rik; eri-1; Eri1; RGD1308378; Thex1
UniProt ID: (Rat) Q5FVR4, (Mouse) Q7TMF2
Entrez Gene ID: (Rat) 361159, (Mouse) 67276
3'-5'-exoribonuclease activity
3'-5' exonuclease activity
rRNA binding
ribosome binding
metal ion binding
histone pre-mRNA stem-loop binding
nucleic acid binding
RNA binding
nuclease activity
exonuclease activity
hydrolase activity
phosphoric ester hydrolase activity
T/G mismatch-specific endonuclease activity
retroviral 3' processing activity
exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
gene silencing by RNA
rRNA 3'-end processing
histone mRNA catabolic process
DNA catabolic process, exonucleolytic
rRNA processing
nucleic acid phosphodiester bond hydrolysis
