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产品信息
PA5-13921
应用
建议稀释比
已发表文章
产品规格
种属反应
Human
已发表种属
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
KLH conjugated synthetic peptide between 39-72 amino acids from the N-terminal region of human ERN2
偶联物
形式
Liquid
浓度
2 mg/mL
纯化类型
Size-exclusion - Dialysis, Ammonium sulfate precipitation
保存液
PBS, pH 7.4
内含物
0.09% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2098730
靶标信息
ERN2 serine/threonine kinase or endoplasmic reticulum to nucleus signaling 2 protein is a human homologue of the yeast Ire1 gene product which plays a role in multiple facets of the ER stress response in mammalian cells. This pro-apoptotic appears to play no role in the unfolded-protein response, unlike closely related proteins. Overexpression of ERN2 activates both BiP and CHOP expression, and also leads to the development of programmed cell death. It has been suggested that Ern2 plays a role in multiple facets of the ER stress response in mammalian cells.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: endoplasmic reticulum to nucleus signalling 2; Endoplasmic reticulum-to-nucleus signaling 2; ER to nucleus signalling 2; hIRE2p; inositol-requiring 1 beta; Inositol-requiring protein 2; IRE1 beta; IRE1, S. cerevisiae, homolog of; Ire1-beta; IRE1b; Serine/threonine-protein kinase/endoribonuclease IRE2
基因别名: ERN2; hIRE2p; IRE1-BETA; IRE1b; IRE2; IRE2p
UniProt ID: (Human) Q76MJ5
Entrez Gene ID: (Human) 10595
