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ESRRA Antibody (PA5-28390) in IHC (P)
ESRRA Polyclonal Antibody detects ERR alpha protein at cytoplasm and nucleus by immunohistochemical analysis. Sample: Paraffin-embedded human intestine. ERR alpha stained by ESRRA Polyclonal Antibody (Product # PA5-28390) diluted at 1:500. Antigen Retrieval: Citrate buffer, pH 6.0, 15 min.
产品信息
PA5-28390
应用
建议稀释比
已发表文章
产品规格
种属反应
Human
已发表种属
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant fragment corresponding to a region within amino acids 69 and 359 of Human ERR alpha
偶联物
形式
Liquid
浓度
0.93 mg/mL
纯化类型
Antigen affinity chromatography
保存液
0.1M tris glycine, pH 7, with 20% glycerol
内含物
0.01% thimerosal
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_2545866
产品详细信息
Recommended positive controls: 293T.
Predicted reactivity: Mouse (98%), Rat (98%), Dog (98%), Pig (99%), Bovine (99%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
靶标信息
Estrogen-related receptor alpha 1 (ERR alpha, ERR1) is an orphan member of the nuclear hormone receptor superfamily. All the ERR family members share an almost identical DNA-binding domain, which has 68% amino acid identity with that of estrogen receptor. This protein binds to an ERR-alpha response element (ERRE) containing a single consensus half-site, 5'-tnaaggtca-3' can bind to the medium-chain acyl coenzyme a dehydrogenase (mcad) response element nrre-1 and may act as an important regulator of mcad promoter. Studies have shown that ERR1 functions a metabolic regulator and is often expressed in tissues that preferentially metabolize fatty acids. The corresponding gene for the ERR1 is NR3B1.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: ERR alpha; ERR-alpha; Estrogen receptor-like 1; estrogen-related nuclear receptor alpha; Estrogen-related receptor alpha; HERR1; Nuclear receptor subfamily 3 group B member 1; Steroid hormone receptor ERR1
基因别名: ERR1; ERRa; ERRalpha; ESRL1; ESRRA; NR3B1
UniProt ID: (Human) P11474
Entrez Gene ID: (Human) 2101
RNA polymerase II core promoter proximal region sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding
DNA binding
steroid hormone receptor activity
RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding
steroid binding
protein binding
zinc ion binding
protein domain specific binding
sequence-specific DNA binding
negative regulation of transcription from RNA polymerase II promoter
regulation of transcription, DNA-templated
transcription initiation from RNA polymerase II promoter
mitochondrion organization
intracellular receptor signaling pathway
response to estradiol
regulation of cell proliferation
steroid hormone mediated signaling pathway
regulation of osteoblast differentiation
regulation of osteoclast differentiation
positive regulation of transcription from RNA polymerase II promoter
cartilage development
positive regulation of cellular response to insulin stimulus
