Invitrogen

ETS2 Monoclonal Antibody (OTI2A3)

ETS2 Antibody in Immunocytochemistry (ICC/IF)

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ETS2 Antibody (MA5-26125) in ICC/IF

Immunofluorescent analysis of ETS2 in COS7 cells. Cells were transfected with a plasmid overexpressing ETS2 and probed with a ETS2 monoclonal antibody (Product # MA5-26125).

ETS2 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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产品信息

MA5-26125

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1:2,000

免疫组化（石蜡） (IHC (P))

1:150

免疫细胞化学 (ICC/IF)

1:100

产品规格

种属反应

Human

宿主/亚型

Mouse / IgG1

分类

Monoclonal

类型

Antibody

克隆号

OTI2A3

抗原

Human recombinant protein fragment corresponding to amino acids 90-349 of ETS2 produced in E.coli

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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1 mg/mL

纯化类型

Affinity Chromatography

保存液

PBS, pH 7.3, with 1% BSA, 50% glycerol

内含物

0.02% sodium azide

保存条件

-20° C, Avoid Freeze/Thaw Cycles

运输条件

Ambient (domestic); Wet ice (international)

AB_2723147

靶标信息

ETS transcriptions factors, such as ETS2, regulate numerous genes and are involved in stem cell development, cell senescence and death, and tumorigenesis. The conserved ETS domain within these proteins is a winged helix-turn-helix DNA-binding domain that recognizes the core consensus DNA sequence GGAA/T of target genes.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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引用该产品

生物信息学

蛋白别名: oncogene ETS-2; Protein C-ets-2; v-ets avian erythroblastosis virus E2 oncogene homolog 2; v-ets avian erythroblastosis virus E26 oncogene homolog 2; v-ets erythroblastosis virus E26 oncogene homolog 2

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基因别名: ETS2; ETS2IT1

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UniProt ID: (Human) P15036

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Entrez Gene ID: (Human) 2114

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功能

RNA polymerase II core promoter proximal region sequence-specific DNA binding transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding DNA binding transcription factor activity, sequence-specific DNA binding protein binding glucocorticoid receptor binding winged helix/forkhead transcription factor

参与通路

negative regulation of transcription from RNA polymerase II promoter skeletal system development ectodermal cell fate commitment transcription, DNA-templated mesoderm development cell differentiation positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter primitive streak formation