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产品信息
MA5-24392
产品规格
种属反应
Human
宿主/亚型
Mouse
/ IgG2b, kappa
分类
Monoclonal
类型
Antibody
克隆号
1C11
抗原
ETV3 (AAH22868, 1 a.a. ~ 143 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
偶联物
形式
Liquid
纯化类型
Protein A
保存液
PBS, pH 7.4
内含物
no preservative
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2633364
产品详细信息
Peptide Sequence: MKAGCSIVEK PEGGGGYQFP DWAYKTESSP GSRQIQLWHF ILELLQKEEF RHVIAWQQGE YGEFVIKDPD EVARLWGRRK CKPQMNYDKL SRALRYYYNK RILHKTKGKR FTYKFNFNKL VMPNYPFINI RSSGKIQTLL VGN
靶标信息
Transcriptional repressor that contribute to growth arrest during terminal macrophage differentiation by repressing target genes involved in Ras-dependent proliferation. Represses MMP1 promoter activity.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: ETS domain transcriptional repressor PE1; ETS translocation variant 3; ets variant gene 3, ETS family transcriptional repressor; Mitogenic Ets transcriptional suppressor; PE-1
基因别名: bA110J1.4; ETV3; METS; PE-1; PE1
UniProt ID: (Human) P41162
Entrez Gene ID: (Human) 2117
RNA polymerase II regulatory region sequence-specific DNA binding
RNA polymerase II transcription factor activity, sequence-specific DNA binding
transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding
molecular_function
DEAD/H-box RNA helicase binding
winged helix/forkhead transcription factor
negative regulation of transcription from RNA polymerase II promoter
transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
biological_process
negative regulation of cell proliferation
cell differentiation
cellular response to granulocyte macrophage colony-stimulating factor stimulus
