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产品信息
PA5-20526
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A 14 amino acid peptide from near the center of human EVER2.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS
内含物
0.02% sodium azide
保存条件
Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_11153881
产品详细信息
A suggested positive control is Jurkat cell lysate.
PA5-20526 can be used with blocking peptide PEP-0646.
靶标信息
Epidermodysplasia verruciformis (EV) is an autosomal recessive genodermatosis associated with a high risk of skin cancers resulting from a high susceptibility to infection by specific human papillomaviruses. Mutations in two homologous genes EVER1 and EVER2 cause the majority of EV cases. These two proteins form a complex and interact with the zinc transporter ZnT-1 in the endoplasmic reticulum. Cells lacking EVER2 accumulated higher levels of zinc in the nucleolus and nucleus compare to those cells with and intact EVER2 gene, indicating that one role of EVER2 is to regulate the intracellular distribution of zinc.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: epidermodysplasia verruciformis 2; Epidermodysplasia verruciformis protein 2; Epidermodysplasia verruciformis protein 2 homolog; transmembrane channel-like 8; Transmembrane channel-like protein 8
基因别名: EV2; EVER2; EVIN2; mFLJ00400; TMC8
UniProt ID: (Human) Q8IU68, (Mouse) Q7TN58
Entrez Gene ID: (Human) 147138, (Mouse) 217356, (Rat) 688276
