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产品信息
PA5-52218
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant protein corresponding to Human EXD2. Recombinant protein control fragment (Product #RP-89042).
偶联物
形式
Liquid
浓度
0.75 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.2, with 40% glycerol
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_2641156
产品详细信息
Immunogen sequence: TSCHAISNYY DNHLKQQLAK EFQAPIGSEE GLRLLEDPER RQVRSGARAL LNAESLPTQR KEELLQALRE FYNTDVVTEE MLQEAASLET RISNENYVPH GLKVVQCH
Highest antigen sequence identity to the following orthologs: Mouse - 90%, Rat - 92%.
靶标信息
Exonuclease that has both 3'-5' exoribonuclease and exodeoxyribonuclease activities, depending on the divalent metal cation used as cofactor (PubMed:29335528, PubMed:31127291). In presence of Mg(2+), only shows 3'-5' exoribonuclease activity, while it shows both exoribonuclease and exodeoxyribonuclease activities in presence of Mn(2+) (PubMed:29335528, PubMed:31127291). Acts as an exoribonuclease in mitochondrion, possibly by regulating ATP production and mitochondrial translation (PubMed:29335528). Also involved in the response to DNA damage (PubMed:26807646, PubMed:31255466). Acts as 3'-5' exodeoxyribonuclease for double-strand breaks resection and efficient homologous recombination (PubMed:20603073, PubMed:26807646). Plays a key role in controlling the initial steps of chromosomal break repair, it is recruited to chromatin in a damage-dependent manner and functionally interacts with the MRN complex to accelerate resection through its 3'-5' exonuclease activity, which efficiently processes double-stranded DNA substrates containing nicks (PubMed:26807646). Also involved in response to replicative stress: recruited to stalled forks and is required to stabilize and restart stalled replication forks by restraining excessive fork regression, thereby suppressing their degradation (PubMed:31255466). [UniProt]
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: 3'-5' exoribonuclease EXD2; exonuclease 3''-5'' domain-like 2; Exonuclease 3'-5' domain-containing protein 2; exonuclease 3'-5' domain-like 2; Exonuclease 3'-5' domain-like-containing protein 2
基因别名: 4930539P14Rik; C14orf114; C85658; EXD2; EXDL2
UniProt ID: (Human) Q9NVH0, (Mouse) Q8VEG4
Entrez Gene ID: (Human) 55218, (Mouse) 97827
