Search Thermo Fisher Scientific
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
FIGURE: 1 / 3
EXO1 Antibody (PA5-29058) in ICC/IF
Immunocytochemistry-Immunofluorescence analysis of EXO1 was performed in HCT116 cells fixed in 4% paraformaldehyde at RT for 15 min. Green: EXO1 Polyclonal Antibody (Product # PA5-29058) diluted at 1:1000. Red: phalloidin, a cytoskeleton marker. Blue: Hoechst 33342 staining.
Product Details
PA5-29058
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant fragment corresponding to a region within amino acids 474 and 753 of Human Exonuclease 1
Conjugate
Form
Liquid
Concentration
2 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7, with 20% glycerol
Contains
0.025% ProClin 300
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Wet ice
RRID
AB_2546534
Product Specific Information
Recommended positive controls: Jurkat, NCI-H929, Mouse thymus.
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Required for muscle atrophy following denervation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
References (0)
Have you cited this product in a publication?
Let us know so we can reference it here.
Bioinformatics
Protein Aliases: Exonuclease 1; Exonuclease I; hExo1; hExoI; mExo1; rad2 nuclease family member, homolog of S. cerevisiae exonuclease 1
Gene Aliases: 5730442G03Rik; EXO1; EXOI; HEX1; hExoI; Msa
UniProt ID: (Human) Q9UQ84, (Mouse) Q9QZ11
Entrez Gene ID: (Human) 9156, (Mouse) 26909
DNA binding
chromatin binding
RNA-DNA hybrid ribonuclease activity
exonuclease activity
protein binding
5'-3' exonuclease activity
5'-3' exodeoxyribonuclease activity
single-stranded DNA 5'-3' exodeoxyribonuclease activity
metal ion binding
flap endonuclease activity
double-stranded DNA 5'-3' exodeoxyribonuclease activity
catalytic activity
nuclease activity
endonuclease activity
hydrolase activity
hydrolase activity, acting on ester bonds
phosphoric ester hydrolase activity
structure-specific DNA binding
T/G mismatch-specific endonuclease activity
retroviral 3' processing activity
exodeoxyribonuclease
DNA synthesis involved in DNA repair
strand displacement
humoral immune response mediated by circulating immunoglobulin
DNA replication
DNA repair
mismatch repair
DNA recombination
somatic hypermutation of immunoglobulin genes
isotype switching
meiotic cell cycle
RNA phosphodiester bond hydrolysis, endonucleolytic
regulation of signal transduction by p53 class mediator
immune system process
nucleobase-containing compound metabolic process
cellular response to DNA damage stimulus
nucleic acid phosphodiester bond hydrolysis
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn more
We're here to help
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support