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产品信息
PA5-23980
产品规格
种属反应
Hamster,
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
KLH conjugated synthetic peptide between 166-193 amino acids from the central region of human DEM1
偶联物
形式
Liquid
浓度
2.0 mg/mL
纯化类型
Protein A, Antigen affinity chromatography
保存液
PBS, pH 7.4
内含物
0.09% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2541480
靶标信息
Single-stranded DNA (ssDNA) bidirectional exonuclease involved in DNA repair. Probably involved in DNA repair following ultraviolet (UV) irradiation and interstrand cross-links (ICLs) damage. Has both 5'-3' and 3'-5' exonuclease activities with a strong preference for 5'-ends. Acts as a sliding exonuclease that loads at ssDNA ends and then slides along the ssDNA prior to cutting; however the sliding and the 3'-5' exonuclease activities are abolished upon binding to the replication protein A (RPA) complex that enforces 5'- directionality activity.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: defects in morphology 1 homolog; Defects in morphology protein 1 homolog; Defects in morphology protein 1-like; Exo V; exonuclease 5; Exonuclease V; probable exonuclease V
基因别名: 3110037I16Rik; AV297100; C1orf176; DEM1; Exo V; EXO5; hExo5; mExo5
UniProt ID: (Human) Q9H790, (Mouse) Q9CXP9
Entrez Gene ID: (Human) 64789, (Mouse) 73172, (Chinese hamster) 100753327
DNA binding
single-stranded DNA 3'-5' exodeoxyribonuclease activity
protein homodimerization activity
single-stranded DNA 5'-3' exodeoxyribonuclease activity
metal ion binding
4 iron, 4 sulfur cluster binding
nuclease activity
exonuclease activity
hydrolase activity
phosphoric ester hydrolase activity
T/G mismatch-specific endonuclease activity
retroviral 3' processing activity
iron-sulfur cluster binding
