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Product Details
PA5-31118
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant fragment corresponding to a region within amino acids 1 and 261 of Human EXOSC8
Conjugate
Form
Liquid
Concentration
0.42 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
0.1M tris glycine, pH 7, with 20% glycerol
Contains
0.01% thimerosal
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Wet ice
RRID
AB_2548592
Product Specific Information
Recommended positive controls: A549, HeLa, HepG2, HCT116, Jurkat, Raji, NCI-H929.
Predicted reactivity: Mouse (91%), Rhesus Monkey (99%), Bovine (93%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
This gene encodes a 3'-5' exoribonuclease that specifically interacts with mRNAs containing AU-rich elements. The encoded protein is part of the exosome complex that is important for the degradation of numerous RNA species. A pseudogene of this gene is found on chromosome 6.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CBP-interacting protein 3; Exosome complex component RRP43; exosome complex exonuclease RRP43; Exosome component 8; OIP-2; Opa interacting protein 2; Opa-interacting protein 2; p9; Ribosomal RNA-processing protein 43; RP11-421P11.3
Gene Aliases: bA421P11.3; CIP3; EAP2; EXOSC8; OIP2; p9; PCH1C; RRP43; Rrp43p
UniProt ID: (Human) Q96B26
Entrez Gene ID: (Human) 11340
exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
rRNA processing
biological_process
nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5'
U1 snRNA 3'-end processing
U4 snRNA 3'-end processing
U5 snRNA 3'-end processing
regulation of mRNA stability
exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay
nuclear mRNA surveillance
nuclear polyadenylation-dependent rRNA catabolic process
nuclear polyadenylation-dependent tRNA catabolic process
nuclear polyadenylation-dependent mRNA catabolic process
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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