Invitrogen

EYA1 Polyclonal Antibody

View all (8) EYA1 antibodies
Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers

Product Details

PA5-117158

Applications
Tested Dilution
Publications

Western Blot (WB)

1:200-1:2,000
-

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:200
-

ELISA (ELISA)

1 µg/mL
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

A synthetic peptide corresponding to a sequence within amino acids 200-300 of human EYA1 (NP_0004942)
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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1.85 mg/mL

Purification

Affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.01% thimerosal

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Shipping conditions

Wet ice

RRID

AB_2901788

Product Specific Information

Positive Samples: SH-SY5Y, 293T, Mouse testis, Mouse brain, Rat brain

Immunogen sequence: NSLTNSSGFN SSQQDYPSYP SFGQGQYAQY YNSSPYPAHY MTSSNTSPTT PSTNATYQLQ EPPSGITSQA VTDPTAEYST IHSPSTPIKD SDSDRLRRGS D

Target Information

This gene encodes a member of the eyes absent family of proteins. The encoded protein may play a role in the developing kidney, branchial arches, eye, and ear. Mutations of this gene have been associated with branchiootorenal dysplasia syndrome, branchiootic syndrome, and sporadic cases of congenital cataracts and ocular anterior segment anomalies. A similar protein in mice can act as a transcriptional activator. Four transcript variants encoding three distinct isoforms have been identified for this gene.

⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: EYA transcriptional coactivator and phosphatase 1; Eyes absent; eyes absent 1 homolog; Eyes absent homolog 1; MGC141875; OTTHUMP00000195053

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Gene Aliases: BOP; BOR; BOS1; EYA1; OFC1

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UniProt ID: (Human) Q99502, (Mouse) P97767

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Entrez Gene ID: (Human) 2138, (Mouse) 14048, (Rat) 502935

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Function(s)
RNA binding protein tyrosine phosphatase activity protein binding metal ion binding phosphoprotein phosphatase activity hydrolase activity molecular_function
Process(es)
establishment of mitotic spindle orientation metanephros development branching involved in ureteric bud morphogenesis outflow tract morphogenesis double-strand break repair transcription, DNA-templated pattern specification process mesodermal cell fate specification sensory perception of sound anatomical structure morphogenesis response to ionizing radiation striated muscle tissue development histone dephosphorylation protein sumoylation cellular protein localization establishment or maintenance of apical/basal cell polarity peptidyl-tyrosine dephosphorylation aorta morphogenesis outer ear morphogenesis middle ear morphogenesis regulation of neuron differentiation positive regulation of DNA repair positive regulation of Notch signaling pathway positive regulation of transcription from RNA polymerase II promoter neuron fate specification embryonic skeletal system morphogenesis semicircular canal morphogenesis positive regulation of epithelial cell proliferation pharyngeal system development lung epithelial cell differentiation otic vesicle morphogenesis positive regulation of secondary heart field cardioblast proliferation cochlea morphogenesis negative regulation of extrinsic apoptotic signaling pathway in absence of ligand ureteric bud development DNA repair regulation of transcription, DNA-templated protein dephosphorylation cellular response to DNA damage stimulus multicellular organism development organ morphogenesis chromatin modification ear morphogenesis inner ear morphogenesis cell fate commitment positive regulation of transcription, DNA-templated anatomical structure development otic vesicle development biological_process
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