Bethyl Laboratories

EYA2 Polyclonal Antibody

EYA2 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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EYA2 Antibody (IHC-00736) in IHC (P)

Detection of human EYA2 by immunohistochemistry. Sample: FFPE section of human breast carcinoma. Antibody: Affinity purified rabbit anti-EYA2 (Product # IHC-00736) used at a dilution of 1:250 Detection: DAB.

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产品信息

IHC-00736

应用

建议稀释比

已发表文章

免疫组化 (IHC)

1:100-1:500

免疫组化（石蜡） (IHC (P))

1:100-1:500

产品规格

种属反应

Human

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

Region between residue 100 and 150 of human eyes absent homolog 2.

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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

50 µg/mL

纯化类型

Antigen affinity chromatography

保存液

TBS, pH 7.0 to 8.0, with 0.1% BSA

内含物

0.09% sodium azide

保存条件

4° C

运输条件

Wet ice

产品详细信息

The recommended shelf life for this product is 1 year from date of receipt.

Based on 100% sequence identity, this antibody is predicted to react with Bovine, Horse, Orangutan, Monkey, Gorilla, Chimpanzee, Northern white-cheeked gibbon, Little brown bat and Small-eared galago

靶标信息

Functions both as protein phosphatase and as transcriptional coactivator for SIX1, and probably also for SIX2, SIX4 and SIX5. Tyrosine phosphatase that dephosphorylates 'Tyr- 142' of histone H2AX (H2AXY142ph) and promotes efficient DNA repair via the recruitment of DNA repair complexes containing MDC1. 'Tyr-142' phosphorylation of histone H2AX plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress. Its function as histone phosphatase may contribute to its function in transcription regulation during organogenesis. Plays an important role in hypaxial muscle development together with SIX1 and DACH2; in this it is functionally redundant with EYA1.

仅用于科研。不用于诊断过程。未经明确授权不得转售。