Invitrogen

EYA2 Polyclonal Antibody

EYA2 Antibody in Immunohistochemistry (IHC)

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EYA2 Antibody (PA5-55487) in IHC

Immunohistochemical staining of EYA2 in human cervix, uterine using EYA2 Polyclonal Antibody (Product # PA5-55487) shows strong nuclear positivity in squamous epithelial cells.

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产品信息

PA5-55487

应用

建议稀释比

已发表文章

免疫印迹 (WB)

0.04-0.4 µg/mL

免疫组化（石蜡） (IHC (P))

1:200-1:500

产品规格

种属反应

Human

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

Recombinant protein corresponding to Human EYA2. Recombinant protein control fragment (Product #RP-91554).

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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

0.2 mg/mL

纯化类型

Antigen affinity chromatography

保存液

PBS, pH 7.2, with 40% glycerol

内含物

0.02% sodium azide

保存条件

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

运输条件

Wet ice

AB_2641176

产品详细信息

Immunogen sequence: GTTGFYQGGN GLGNAAGFGS VHQDYPSYPG FPQSQYPQYY GSSYNPPYVP ASSICPSPLS TSTYVLQEAS HNVPNQSSES LAGEYNTHNG PSTPAKEGDT DRPHRASDGK LRGRSKRSSD PSPAGDNEIE RVFVWDLD

Highest antigen sequence identity to the following orthologs: Mouse - 86%, Rat - 88%.

靶标信息

Functions both as protein phosphatase and as transcriptional coactivator for SIX1, and probably also for SIX2, SIX4 and SIX5. Tyrosine phosphatase that dephosphorylates 'Tyr- 142' of histone H2AX (H2AXY142ph) and promotes efficient DNA repair via the recruitment of DNA repair complexes containing MDC1. 'Tyr-142' phosphorylation of histone H2AX plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress. Its function as histone phosphatase may contribute to its function in transcription regulation during organogenesis. Plays an important role in hypaxial muscle development together with SIX1 and DACH2; in this it is functionally redundant with EYA1.

仅用于科研。不用于诊断过程。未经明确授权不得转售。