Invitrogen

EYA4 Polyclonal Antibody

EYA4 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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EYA4 Antibody (PA5-58534) in IHC (P)

Immunohistochemical analysis of EYA4 in human testis using EYA4 Polyclonal Antibody (Product # PA5-58534) shows moderate nuclear positivity in a small subset of cells in seminiferous ducts.

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产品信息

PA5-58534

应用

建议稀释比

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免疫印迹 (WB)

0.04-0.4 µg/mL

免疫组化（石蜡） (IHC (P))

1:20-1:50

产品规格

种属反应

Human, Mouse, Rat

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

Recombinant protein corresponding to Human EYA4. Recombinant protein control fragment (Product #RP-94980).

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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

0.1 mg/mL

纯化类型

Antigen affinity chromatography

保存液

PBS, pH 7.2, with 40% glycerol

内含物

0.02% sodium azide

保存条件

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

运输条件

Wet ice

AB_2641180

产品详细信息

Immunogen sequence: QYAQYYSAST YGAYMTSNNT ADGTPSSTST YQLQESLPGL TNQPGEFDTM QSPSTPIKDL DERTCRSSGS KS

Highest antigen sequence identity to the following orthologs: Mouse - 93%, Rat - 93%.

靶标信息

This gene encodes a member of the eyes absent (EYA) family of proteins. The encoded protein may act as a transcriptional activator through its protein phosphatase activity, and it may be important for eye development, and for continued function of the mature organ of Corti. Mutations in this gene are associated with postlingual, progressive, autosomal dominant hearing loss at the deafness, autosomal dominant non-syndromic sensorineural 10 locus. The encoded protein is also a putative oncogene that mediates DNA repair, apoptosis, and innate immunity following DNA damage, cellular damage, and viral attack. Defects in this gene are also associated with dilated cardiomyopathy 1J. Alternative splicing results in multiple transcript variants encoding distinct isoforms.

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