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Invitrogen
Endothelin A Receptor Recombinant Rabbit Monoclonal Antibody (15H24L16)
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Endothelin A Receptor Antibody (704014) in ICC/IF
HEK-293 cells stably transfected with EDNRA were grown on poly-L-lysine-coated coverslips overnight. After 24 h, cells were fixed with 4% paraformaldehyde and 0.2% picric acid in phosphate buffer (pH 6.9) for 30 min at room temperature and washed several times with phosphate buffer. Specimens were permeabilized with ice-cold methanol and then incubated with EDNRA Recombinant Rabbit Monoclonal Antibody (Prod... View More
产品信息
704014
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
Expression System
Expi293
分类
Recombinant Monoclonal
类型
Antibody
克隆号
15H24L16
抗原
Peptide corresponding to residues aa 408-427 of human EDNRA
偶联物
形式
Liquid
浓度
0.5 mg/mL
纯化类型
Protein A
保存液
PBS, pH 7.4
内含物
0.09% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_3073995
产品详细信息
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. Recombinant antibodies are produced using specific genes that code for the desired antibodies. These genes are cloned into an expression vector and expressed in vitro. The advantages of recombinant antibodies include better specificity and lot-to-lot consistency.
It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest.
靶标信息
This gene encodes the receptor for endothelin-1, a peptide that plays a role in potent and long-lasting vasoconstriction. This receptor associates with guanine-nucleotide-binding (G) proteins, and this coupling activates a phosphatidylinositol-calcium second messenger system. Polymorphisms in this gene have been linked to migraine headache resistance. Alternative splicing results in multiple transcript variants.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Endothelin A; endothelin receptor subtype A; Endothelin receptor type A; Endothelin-1 receptor; endothelin-1-specific receptor; ET-A; G protein-coupled receptor
基因别名: EDNRA; ET-A; ETA; ETA-R; ETAR; ETRA; hET-AR; MFDA
UniProt ID: (Human) P25101
Entrez Gene ID: (Human) 1909
patterning of blood vessels
response to hypoxia
in utero embryonic development
histamine secretion
glomerular filtration
smooth muscle contraction
signal transduction
G-protein coupled receptor signaling pathway
activation of adenylate cyclase activity
activation of phospholipase C activity
positive regulation of cytosolic calcium ion concentration
protein kinase C-activating G-protein coupled receptor signaling pathway
Rho protein signal transduction
heart development
aging
respiratory gaseous exchange
regulation of blood pressure
cell proliferation
positive regulation of cell proliferation
neural crest cell development
artery smooth muscle contraction
glucose transport
sensory perception of pain
negative regulation of cAMP biosynthetic process
response to lipopolysaccharide
vasoconstriction
positive regulation of odontogenesis
negative regulation of apoptotic process
penile erection
response to morphine
fibroblast proliferation
enteric nervous system development
smooth muscle cell proliferation
regulation of epithelial cell proliferation
positive regulation of inflammatory response
positive regulation of release of sequestered calcium ion into cytosol
positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway
maternal process involved in parturition
head development
positive regulation of ERK1 and ERK2 cascade
cellular response to mechanical stimulus
endothelin receptor signaling pathway
positive regulation of neutrophil chemotaxis
positive regulation of kidney development
