Search Thermo Fisher Scientific
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
产品信息
MA5-47665
应用
建议稀释比
已发表文章
产品规格
种属反应
Human
宿主/亚型
Mouse
/ IgG1
分类
Monoclonal
类型
Antibody
克隆号
M049
抗原
Clone (M049) was generated from a recombinant protein that included the extracellular region of human EphA2 protein.
偶联物
形式
Liquid
浓度
0.25 mg/mL
纯化类型
Protein G
保存液
PBS with 1mg/mL BSA, 50% glycerol
内含物
0.05% sodium azide
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Wet ice
RRID
AB_2942646
产品详细信息
Clone M049 mouse monoclonal antibody detects a 125kDa* protein on SDS-PAGE "Native" immunoblots of human NCI-H2052 and MDA-MB-231 carcinomas, as well as the EphA2 C-terminal 60 kDa fragment in human A431 and A549. The antibody detects native EphA2, as well as aldehyde-fixed EphA2. The antibody works for Native western blot, immunoprecipitation, immunocytochemistry, and ELISA capture.
靶标信息
EPHA2 belongs to the ephrin receptor subfamily of the protein tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediated developmental events, particularly in the nervous system. EPHA2 is overexpressed in many types of human cancers. The tyrosine kinase (TK) group is mainly involved in the regulation of cell-cell interactions such as differentiation, adhesion, motility and death. There are currently about 90 TK genes sequenced, 58 are of receptor protein TK (e.g. EGFR, EPH, FGFR, PDGFR, TRK, and VEGFR families), and 32 of cytosolic TK (e.g. ABL, FAK, JAK, and SRC families).
仅用于科研。不用于诊断过程。未经明确授权不得转售。
篇参考文献 (0)
您是否在文献中引用过该产品？请点击下方按钮邮件告知我们。
生物信息学
蛋白别名: Ephrin type-A receptor 2; Epithelial cell kinase; epithelial cell receptor protein tyrosine kinase; soluble EPHA2 variant 1; Tyrosine-protein kinase receptor ECK
基因别名: ARCC2; CTPA; CTPP1; CTRCT6; ECK; EPHA2
UniProt ID: (Human) P29317
Entrez Gene ID: (Human) 1969
skeletal system development
angiogenesis
vasculogenesis
osteoblast differentiation
multicellular organism development
intrinsic apoptotic signaling pathway in response to DNA damage
regulation of lamellipodium assembly
notochord formation
viral process
cell migration
peptidyl-tyrosine phosphorylation
neural tube development
neuron differentiation
keratinocyte differentiation
osteoclast differentiation
mammary gland epithelial cell proliferation
regulation of cell adhesion mediated by integrin
post-anal tail morphogenesis
protein kinase B signaling
regulation of blood vessel endothelial cell migration
regulation of angiogenesis
bone remodeling
ephrin receptor signaling pathway
axial mesoderm formation
negative regulation of protein kinase B signaling
notochord cell development
cell chemotaxis
branching involved in mammary gland duct morphogenesis
lens fiber cell morphogenesis
regulation of ERK1 and ERK2 cascade
response to growth factor
positive regulation of establishment of protein localization to plasma membrane
activation of GTPase activity
cell-cell adhesion
