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产品信息
PA5-95075
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthetic peptide corresponding to a sequence at the N-terminus of human ErbB 4 (35-51aa KLSSLSDLEQQYRALRK).
偶联物
形式
Lyophilized
浓度
500 µg/mL
纯化类型
Affinity chromatography
保存液
PBS with 5mg BSA
内含物
0.05mg sodium azide, 0.05mg thimerosal
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2806881
产品详细信息
Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 µg/mL.
靶标信息
Oncogene ERBB4 (HER4) is a member of the type I receptor protein tyrosine subfamily that includes EGFR, ERBB2, and ERBB3. ERBB4 binds and is activated by neuregulins and other factors and induces a variety of cellular responses including mitogenesis and differentiation. ErbB 4 is activated by neuregulins and NTAK (neural and thymus derived activator for ErbB kinases). ErbB 4 is a receptor for heregulin and is capable of mediating HGL-stimulated tyrosine phosphorylation of itself. Like other protein kinases, ErbB 4 mediate most of the signal transduction in eukaryotic cells, regulating cellular metabolism, transcription, cell cycle progression, cytoskeletal rearrangement and cell movement, apoptosis, and differentiation. ErbB 4 is most predominantly expressed in several breast carcinoma cell lines, and in normal skeletal muscle, heart, pituitary, brain, and cerebellum. Breast tumor cell lines T47-D, MDA-MB-453, BT-474 and H3396 are found to have the highest levels of mRNA, and intermediate levels are seen in MCF-7, MDAMB-330 and MDA-MB-361. Expression of ErbB 4 is low or absent in some breast tumor cell lines such as MDA-MB-231, MDA-MB-157, MDA-MB-468, and SKBR-3. ErbB 4 levels have been found to be elevated in certain human tumor cell lines suggesting that it may play a role in some malignancies.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: avian erythroblastic leukemia viral (v-erb-b2) oncogene homolog 4; avian erythroblastosis oncogene B 4; c-erbB-4; ERBB4 transcript variant I12DEL; ERBB4 transcript variant I20DEL; human epidermal growth factor receptor 4; OTTHUMP00000209432; p180erbB4; Proto-oncogene-like protein c-ErbB-4; receptor tyrosine kinase; Receptor tyrosine-protein kinase erbB-4; Tyrosine kinase-type cell surface receptor HER4; v-erb-a erythroblastic leukemia viral oncogene homolog 4; v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 4
基因别名: ALS19; c-erbB-4; ERBB4; HER4; Mer4; p180erbB4; Tyro-2
UniProt ID: (Human) Q15303, (Mouse) Q61527, (Rat) Q62956
Entrez Gene ID: (Human) 2066, (Mouse) 13869, (Rat) 59323
protein tyrosine kinase activity
transmembrane receptor protein tyrosine kinase activity
receptor signaling protein tyrosine kinase activity
Ras guanyl-nucleotide exchange factor activity
epidermal growth factor receptor binding
protein binding
ATP binding
protein homodimerization activity
transcription regulatory region DNA binding
phosphatidylinositol-4,5-bisphosphate 3-kinase activity
nucleotide binding
protein kinase activity
kinase activity
transferase activity
transferase activity, transferring phosphorus-containing groups
transmembrane signal receptor
MAPK cascade
neural crest cell migration
positive regulation of protein phosphorylation
transcription, DNA-templated
signal transduction
transmembrane receptor protein tyrosine kinase signaling pathway
nervous system development
heart development
lactation
cell proliferation
positive regulation of cell proliferation
negative regulation of cell proliferation
embryonic pattern specification
regulation of phosphatidylinositol 3-kinase signaling
positive regulation of phosphatidylinositol 3-kinase signaling
cell migration
peptidyl-tyrosine phosphorylation
central nervous system morphogenesis
olfactory bulb interneuron differentiation
regulation of cell migration
ERBB2 signaling pathway
positive regulation of tyrosine phosphorylation of Stat5 protein
positive regulation of GTPase activity
mitochondrial fragmentation involved in apoptotic process
cell fate commitment
positive regulation of transcription, DNA-templated
protein autophosphorylation
phosphatidylinositol phosphorylation
phosphatidylinositol-mediated signaling
positive regulation of cardiac muscle cell proliferation
mammary gland epithelial cell differentiation
mammary gland alveolus development
cardiac muscle tissue regeneration
positive regulation of ERK1 and ERK2 cascade
positive regulation of protein localization to cell surface
regulation of cell motility
positive regulation of STAT protein import into nucleus
negative regulation of neuron migration
regulation of transcription, DNA-templated
protein phosphorylation
apoptotic process
multicellular organism development
negative regulation of muscle cell apoptotic process
phosphorylation
positive regulation of cell migration
positive regulation of synaptic transmission, GABAergic
negative regulation of apoptotic process
surfactant homeostasis
positive regulation of glucose import
positive regulation of epithelial cell proliferation
synapse maturation
telencephalon development
signal transduction by protein phosphorylation
mammary gland development
response to progesterone
odontogenesis
response to drug
response to hydrogen peroxide
positive regulation of phosphatidylinositol 3-kinase activity
