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F11R Antibody (H00050848-D01P) in WB
Western Blot analysis of F11R expression in transfected 293T cell line (H00050848-T02) by F11R MaxPab polyclonal antibody.
Lane 1: F11R transfected lysate(32.60 KDa).
Lane 2: Non-transfected lysate.
Lane 1: F11R transfected lysate(32.60 KDa).
Lane 2: Non-transfected lysate.
产品信息
H00050848-D01P
产品规格
种属反应
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
F11R (NP_058642.1, 1 a.a. approximately 299 a.a) full-length human protein.
偶联物
形式
Liquid
浓度
See Label
纯化类型
Affinity chromatography
保存液
PBS, pH 7.4
内含物
no preservative
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Sequence of this protein is as follows: MGTKAQVERK LLCLFILAIL LCSLALGSVT VHSSEPEVRI PENNPVKLSC AYSGFSSPRV EWKFDQGDTT RLVCYNNKIT ASYEDRVTFL PTGITFKSVT REDTGTYTCM VSEEGGNSYG EVKVKLIVLV PPSKPTVNIP SSATIGNRAV LTCSEQDGSP PSEYTWFKDG IVMPTNPKST RAFSNSSYVL NPTTGELVFD PLSASDTGEY SCEARNGYGT PMTSNAVRME AVERNVGVIV AAVLVTLILL GILVFGIWFA YSRGHFDRTK KGTSSKKVIY SQPSARSEGE FKQTSSFLV
靶标信息
CD321 (F11R, JAM-1, JAM-A) is a cell-surface adhesion molecule belonging to the Ig superfamily of receptors. CD321 is a 32-41 kD glycoprotein, possessing two extracellular Ig-like domains, a transmembrane region, and a short cytosolic tail. The protein assembles at the membrane as a homodimer, and can associate laterally with other membrane proteins including integrins. CD321 is expressed on a variety of cell types, including leukocytes, platelets, erythrocytes, stem cells, epithelial and endothelial cells, and plays a role in mediating cell-cell contact. CD321 can be found in close proximity to several components of epithelial tight junctions, including ZO-1 and occludin. CD321 is involved in the maintenance of epithelial and endothelial barriers, hematopoiesis, angiogenesis, and tumor proliferation, invasion, and metastasis.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: BV11 antigen; CD321; F11 R; F11 receptor/F11R; JAM-1; JAM-A; junction cell adhesion molecule A; junction cell adhesion molecule1; Junctional adhesion molecule 1; Junctional adhesion molecule A; PAM-1; Platelet adhesion molecule 1; Platelet F11 receptor
基因别名: 9130004G24; AA638916; CD321; ESTM33; F11R; JAM; JAM-1; JAM-A; JAM1; JAMA; JCAM; Jcam1; KAT; Ly106; PAM-1; UNQ264/PRO301
UniProt ID: (Human) Q9Y624, (Mouse) O88792
Entrez Gene ID: (Human) 50848, (Mouse) 16456
cell adhesion
viral process
epithelial cell differentiation
actomyosin structure organization
negative regulation of GTPase activity
positive regulation of GTPase activity
positive regulation of blood pressure
intestinal absorption
establishment of protein localization to plasma membrane
establishment of endothelial intestinal barrier
regulation of membrane permeability
regulation of actin cytoskeleton reorganization
regulation of cytokine production
inflammatory response
transforming growth factor beta receptor signaling pathway
response to radiation
extracellular matrix organization
viral entry into host cell
leukocyte migration
bicellular tight junction assembly
cell-cell adhesion
