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F1A alpha Antibody (PA5-88764) in WB
Western blot analysis of F1A alpha in extracts of A-549 cells. Samples were incubated with F1A alpha Polyclonal antibody (Product # PA5-88764) using a dilution of 1:3,000, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit. Exposure time: 90s.
产品信息
PA5-88764
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant fusion protein containing a sequence corresponding to amino acids 368-627 of human FEM1B (NP_0561371)
偶联物
形式
Liquid
浓度
1.56 mg/mL
纯化类型
Affinity Chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.01% thimerosal
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Wet ice
RRID
AB_2805114
产品详细信息
Immunogen sequence: LHALHLRQKG NRNTHKDLLR FAQVFSQMIH LNETVKAPDI ECVLRCSVLE IEQSMNRVKN ISDADVHNAM DNYECNLYTF LYLVCISTKT QCSEEDQCKI NKQIYNLIHL DPRTREGFTL LHLAVNSNTP VDDFHTNDVC SFPNALVTKL LLDCGAEVNA VDNEGNSALH IIVQYNRPIS DFLTLHSIII SLVEAGAHTD MTNKQNKTPL DKSTTGVSEI LLKTQMKMSL KCLAARAVRA NDINYQDQIP RTLEEFVGFH; Positive Samples: A-549; Cellular Location: Cytoplasm, Nucleus
靶标信息
Fas and tumor necrosis factor receptor 1 (TNFR1) are two prototype members in the death receptor family. A novel protein that associates with the intracellular domains of Fas and TNFR1 was recently identified and designated F1Aalpha and FEM1-b. F1Aalpha/FEM1-b is the homologue of C. elegans sex determining protein FEM-1. FEM-1/F1Aalpha is cleaved by CED-3 and caspase. FEM-1/F1Aalpha associates with CED-4 and its mammalian homologue Apaf-1. Overexpression of F1Aalpha induces apoptosis. F1Aalpha is therefore a novel member of the death receptor associated protein that mediates apoptosis. F1Aalpha is expressed in a variety of human and mouse tissues.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: DKFZp451E0710; F1A-alpha; FEM-1-like death receptor binding protein; Fem-1-like death receptor-binding protein alpha; Fem-1-like in apoptotic pathway protein alpha; FEM1-beta; FEM1b; FIAA; Protein fem-1 homolog B
基因别名: F1A-ALPHA; F1AA; FEM1-beta; FEM1B; KIAA0396
UniProt ID: (Human) Q9UK73
Entrez Gene ID: (Human) 10116
apoptotic process
protein ubiquitination
regulation of ubiquitin-protein transferase activity
branching involved in prostate gland morphogenesis
epithelial cell maturation involved in prostate gland development
regulation of extrinsic apoptotic signaling pathway via death domain receptors
regulation of DNA damage checkpoint
