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产品信息
PA5-61367
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant protein corresponding to Human FAM89B. Recombinant protein control fragment (Product #RP-100459).
偶联物
形式
Liquid
浓度
Lot-Specific
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.2, with 40% glycerol
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_2641479
产品详细信息
Immunogen sequence: RKEMLWGLYE SIQDYKHLCQ DLSFCQDLSS SLHSDSSYPP DAGLS
Highest antigen sequence identity to the following orthologs: Mouse - 98%, Rat - 89%.
靶标信息
Negatively regulates TGF-beta-induced signaling; in cooperation with SKI prevents the translocation of SMAD2 from the nucleus to the cytoplasm in response to TGF-beta. Acts as an adapter that mediates the specific recognition of LIMK1 by CDC42BPA and CDC42BPB in the lamellipodia. LRAP25-mediated CDC42BPA/CDC42BPB targeting to LIMK1 and the lamellipodium results in LIMK1 activation and the subsequent phosphorylation of CFL1 which is important for lamellipodial F-actin regulation. [UniProt]
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: family with sequence similarity 89, member B; Leucine repeat adapter protein 25; leucine repeat adaptor protein 25; mammary tumor virus receptor homolog 1
基因别名: FAM89B; LRAP25; MTVR; MTVR1
UniProt ID: (Human) Q8N5H3
Entrez Gene ID: (Human) 23625
