Invitrogen

FANCL Polyclonal Antibody

FANCL Antibody in Immunocytochemistry (ICC/IF)

图: 1 / 5

FANCL Antibody (PA5-57768) in ICC/IF

Immunofluorescent staining of FANCL in human cell line U-2 OS using a FANCL Polyclonal Antibody (Product # PA5-57768) shows localization to nuclear bodies and vesicles.

FANCL Antibody in Immunohistochemistry (Paraffin) (IHC (P))

FANCL Antibody in Immunohistochemistry (IHC)

Product Image Gallery

产品信息

PA5-57768

应用

建议稀释比

已发表文章

免疫印迹 (WB)

0.04-0.4 µg/mL

查看1篇已发表文章 1篇已发表文章

免疫组化（石蜡） (IHC (P))

1:20-1:50

免疫细胞化学 (ICC/IF)

0.25-2 µg/mL

产品规格

种属反应

Human

已发表种属

Human

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

Recombinant protein corresponding to Human FANCL. Recombinant protein control fragment (Product #RP-96017).

查看免疫原

偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

0.2 mg/mL

纯化类型

Antigen affinity chromatography

保存液

PBS, pH 7.2, with 40% glycerol

内含物

0.02% sodium azide

保存条件

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

运输条件

Wet ice

AB_2641499

产品详细信息

Immunogen sequence: ALKNRQELYA LPPPPQFYSS LIEEIGTLGW DKLVYADTCF STIKLKAEDA SGREHLITLK LKAKYPAESP DYFVDFPVPF C

Highest antigen sequence identity to the following orthologs: Mouse - 65%, Rat - 67%.

靶标信息

The Fanconi anemia complementation group (FANC) currently includes FANCA, FANCB, FANCC, FANCD1 (also called BRCA2), FANCD2, FANCE, FANCF, FANCG, FANCI, FANCJ (also called BRIP1), FANCL, FANCM and FANCN (also called PALB2). The previously defined group FANCH is the same as FANCA. Fanconi anemia is a genetically heterogeneous recessive disorder characterized by cytogenetic instability, hypersensitivity to DNA crosslinking agents, increased chromosomal breakage, and defective DNA repair. The members of the Fanconi anemia complementation group do not share sequence similarity; they are related by their assembly into a common nuclear protein complex. This gene encodes the protein for complementation group L. Alternative splicing results in two transcript variants encoding different isoforms.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

Product References

A Surge of DNA Damage Links Transcriptional Reprogramming and Hematopoietic Deficit in Fanconi Anemia.

Molecular cell

Shen X,Wang R,Kim MJ,Hu Q,Hsu CC,Yao J,Klages-Mundt N,Tian Y,Lynn E,Brewer TF,Zhang Y,Arun B,Gan B,Andreeff M,Takeda S,Chen J,Park JI,Shi X,Chang CJ,Jung SY,Qin J,Li L

PA5-57768 was used in Western Blot to show that reprogramming transcription during hematopoietic differentiation results in an overload of genotoxic stress, which causes aborted differentiation and depletion of Fanconi anemia mutant progenitor cells.

Thu Dec 17 00:00:00 UTC 2020

生物信息学

蛋白别名: E3 ubiquitin-protein ligase FANCL; FAAP43; Fanconi anemia group L protein; Fanconi anemia, complementation group L; Fanconi anemia-associated polypeptide of 43 kDa; FLJ10335; PHD finger protein 9; RING-type E3 ubiquitin transferase FANCL

查看更多收起

基因别名: FAAP43; FANCL; PHF9; POG

查看更多收起

UniProt ID: (Human) Q9NW38

查看更多收起

Entrez Gene ID: (Human) 55120

查看更多收起

功能

ubiquitin-protein transferase activity protein binding ligase activity ubiquitin protein ligase binding metal ion binding ubiquitin protein ligase activity ubiquitin-protein ligase protein modifying enzyme

参与通路

positive regulation of defense response to virus by host DNA repair protein monoubiquitination cellular response to DNA damage stimulus gamete generation interstrand cross-link repair regulation of cell proliferation xenophagy