Invitrogen

FAP Monoclonal Antibody (F11-24), eBioscience™

图: 1 / 3

FAP Antibody (BMS168) in Flow

Cancer science 2023 - 2 FIGURE Verification of fibroblast activation protein alpha (FAP-alpha) overexpression, and human and murine FAP-alpha cross-reactivity of AF3715. (A) Immunoblot analysis confirming FAP-alpha overexpression in 231-FAP and HT-1080-FAP cells. (B) Relative FAP-alpha mRNA expression levels (mean +- SD) of prostate cancer-associated fibroblasts (PCAFs), pancreatic cancer-associated fibroblasts (CAF35), MDA-MB-2... View More

FAP Antibody in Immunohistochemistry (IHC)

Product Image Gallery

产品信息

BMS168

应用

建议稀释比

已发表文章

免疫印迹 (WB)

查看1篇已发表文章 1篇已发表文章

免疫组化 (IHC)

Assay-Dependent

查看3篇已发表文章 3篇已发表文章

免疫细胞化学 (ICC/IF)

查看3篇已发表文章 3篇已发表文章

流式细胞分析 (Flow)

Assay-Dependent

查看2篇已发表文章 2篇已发表文章

免疫沉淀 (IP)

Assay-Dependent

产品规格

种属反应

Human

已发表种属

Human

宿主/亚型

Mouse / IgG1

分类

Monoclonal

类型

Antibody

克隆号

F11-24

抗原

Rec. Human FAP

偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1 mg/mL

纯化类型

Protein G

保存液

PBS

内含物

no preservative

保存条件

4° C

运输条件

Ambient (domestic); Wet ice (international)

AB_10597443

产品详细信息

Description: BMS168 (F11-24) specifically reacts with Fibroblast Activation Protein (FAP), a cell surface glycoprotein of reactive human fibroblast. Among the normal adult organs tested BMS168 does not show immunoreactivity in immunohistological studies with either resting fibroblasts (fibrocytes) of the normal organ mesenchyme or the parenchymal cells. The single exception noted is a subset of endocrine cells in the pancreatic islets, presumably glucagon-producing A cells.

Applications Tested: Flow Cytometry, Immunohistochemistry, Immunoprecipitation.

靶标信息

The protein encoded by this gene is a homodimeric integral membrane gelatinase belonging to the serine protease family. It is selectively expressed in reactive stromal fibroblasts of epithelial cancers, granulation tissue of healing wounds, and malignant cells of bone and soft tissue sarcomas. This protein is thought to be involved in the control of fibroblast growth or epithelial-mesenchymal interactions during development, tissue repair, and epithelial carcinogenesis.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

Product References

Evaluating near-infrared photoimmunotherapy for targeting fibroblast activation protein-α expressing cells in vitro and in vivo.

Cancer science

Jin J,Barnett JD,Krishnamachary B,Mironchik Y,Luo CK,Kobayashi H,Bhujwalla ZM

BMS168 was used in Flow Cytometry to find FAP-α expression increased in fibroblasts cocultured with cancer cells.

Sun Jan 01 00:00:00 UTC 2023

COL11A1-driven positive feedback loop modulates fibroblast transformation and activates pancreatic cancer progression.

Cell biology international

Sun D,Dai T,Ji Y,Shen W,Bian W

BMS168 was used in Immunocytochemistry to find that pancreatic ductal adenocarcinoma (PDAC)-derived collagen type XI alpha 1 (COL11A1) promoted the conversion of normal fibroblasts (NFs) to cancer-associated fibroblasts (CAFs)-like cells.

Thu Jun 01 00:00:00 UTC 2023

N6‑methyladenosine upregulates miR‑181d‑5p in exosomes derived from cancer‑associated fibroblasts to inhibit 5‑FU sensitivity by targeting NCALD in colorectal cancer.

International journal of oncology

Pan S,Deng Y,Fu J,Zhang Y,Zhang Z,Qin X

BMS168 was used in Immunocytochemistry to investigate the role of exosomal miRNAs in 5‚Fluorouracil sensitivity and resistance in colorectal cancer.

Tue Feb 01 00:00:00 UTC 2022

TNF antagonist sensitizes synovial fibroblasts to ferroptotic cell death in collagen-induced arthritis mouse models.

Nature communications

Wu J,Feng Z,Chen L,Li Y,Bian H,Geng J,Zheng ZH,Fu X,Pei Z,Qin Y,Yang L,Zhao Y,Wang K,Chen R,He Q,Nan G,Jiang X,Chen ZN,Zhu P

BMS168 was used in Immunohistochemistry, Flow Cytometry to imply that the combination of TNF inhibitors and ferroptosis inducers may serve as a potential candidate for RA therapy.

Thu Feb 03 00:00:00 UTC 2022

TNF antagonist sensitizes synovial fibroblasts to ferroptotic cell death in collagen-induced arthritis mouse models.

Nature communications

Wu J,Feng Z,Chen L,Li Y,Bian H,Geng J,Zheng ZH,Fu X,Pei Z,Qin Y,Yang L,Zhao Y,Wang K,Chen R,He Q,Nan G,Jiang X,Chen ZN,Zhu P

BMS168 was used in Immunohistochemistry, Flow Cytometry to imply that the combination of TNF inhibitors and ferroptosis inducers may serve as a potential candidate for RA therapy.

Thu Feb 03 00:00:00 UTC 2022

Endogenous Galectin-9 Suppresses Apoptosis in Human Rheumatoid Arthritis Synovial Fibroblasts.

Scientific reports

Pearson MJ,Bik MA,Ospelt C,Naylor AJ,Wehmeyer C,Jones SW,Buckley CD,Gay S,Filer A,Lord JM

BMS168 was used in Immunohistochemistry-immunofluorescence to determine the role of endogenous Galectins in the inflammatory pathology of the rheumatoid arthritis synovium in humans.

Mon Aug 27 00:00:00 UTC 2018

IL-6/STAT3 axis initiated CAFs via up-regulating TIMP-1 which was attenuated by acetylation of STAT3 induced by PCAF in HCC microenvironment.

Cellular signalling

Zheng X,Xu M,Yao B,Wang C,Jia Y,Liu Q

BMS168 was used in western blot to examine the mechanisms by which IL-6/STAT3 signaling and TIMP-1 modulate the crosstalk between tumor cells and cancer associated fibroblasts in the tumor microenvironment

Thu Sep 01 00:00:00 UTC 2016

COX/mPGES-1/PGE2 pathway depicts an inflammatory-dependent high-risk neuroblastoma subset.

Proceedings of the National Academy of Sciences of the United States of America

Larsson K,Kock A,Idborg H,Arsenian Henriksson M,Martinsson T,Johnsen JI,Korotkova M,Kogner P,Jakobsson PJ

BMS168 was used in immunohistochemistry to study the involvement of COX/mPGES-1/PGE2 pathway in tumor inflammatory environment

Tue Jun 30 00:00:00 UTC 2015

COX/mPGES-1/PGE2 pathway depicts an inflammatory-dependent high-risk neuroblastoma subset.

Proceedings of the National Academy of Sciences of the United States of America

Larsson K,Kock A,Idborg H,Arsenian Henriksson M,Martinsson T,Johnsen JI,Korotkova M,Kogner P,Jakobsson PJ

BMS168 was used in immunohistochemistry to study the involvement of COX/mPGES-1/PGE2 pathway in tumor inflammatory environment

Tue Jun 30 00:00:00 UTC 2015

Hierarchical paracrine interaction of breast cancer associated fibroblasts with cancer cells via hMAPK-microRNAs to drive ER-negative breast cancer phenotype.

Cancer biology & therapy

Shah SH,Miller P,Garcia-Contreras M,Ao Z,Machlin L,Issa E,El-Ashry D

BMS168 was used in immunocytochemistry to study the role of MAPK-microRNA in the interaction between cancer cells and neighboring fibroblasts

Mon Sep 12 00:00:00 UTC 2016

生物信息学

蛋白别名: 170 kDa melanoma membrane-bound gelatinase; Dipeptidyl peptidase FAP; FAPalpha; Fibroblast activation protein alpha; fibroblast activation protein, alpha; Gelatine degradation protease FAP; Integral membrane serine protease; Post-proline cleaving enzyme; Prolyl endopeptidase FAP; Seprase; Serine integral membrane protease; SIMP; Surface-expressed protease

查看更多收起

基因别名: DPPIV; FAP; FAPA; SIMP

查看更多收起

UniProt ID: (Human) Q12884

查看更多收起

Entrez Gene ID: (Human) 2191

查看更多收起

功能