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产品信息
MA5-46769
产品规格
种属反应
Mouse
宿主/亚型
Rabbit
/ IgG
Expression System
HEK293 cells
分类
Recombinant Monoclonal
类型
Antibody
克隆号
004
抗原
Recombinant protein encoding Mouse FAS (Met1-Arg169).
偶联物
激发/发射光谱
651/660 nm
查看光谱
形式
Liquid
浓度
100 µg/mL
纯化类型
Protein A
保存液
PBS with 0.5% BSA
内含物
0.09% sodium azide
保存条件
4° C, store in dark, DO NOT FREEZE!
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2937841
产品详细信息
Preparation: This antibody was obtained from a rabbit immunized with purified, recombinant Mouse FAS (CD95) (Met1-Arg169) and conjugated with APC under optimum conditions, the unreacted APC was removed.
Storage: This antibody can be stored at 2C-8C for twelve months without detectable loss of activity. Protected from prolonged exposure to light. Do not freeze! Sodium azide is toxic to cells and should be disposed of properly. Flush with large volumes of water during disposal.
靶标信息
FAS (Fas, CD95, APO-1) is a 46 kDa transmembrane glycoprotein that functions as a cell death receptor of the TNFR (tumor necrosis factor receptor) superfamily. FAS also exists in a soluble form that weight approximately 26kDa. Stimulation of FAS results in aggregation of its intracellular FAS-associated death domains (FADD), formation of the death-inducing signaling complex (DISC) and activation of caspases. The auto-proteolytic processing of the caspases in the complex trigger a downstream cascade that leads to apoptosis. FAS has been shown to activate NF-kappaB, MAPK3/ERK1, MAPK8/JNK, and is involved in transducing the proliferating signals in normal diploid fibroblast and T cells. At least eight alternatively spliced transcript variants encoding seven distinct isoforms have been described. The isoforms lacking the transmembrane domain may negatively regulate the apoptosis mediated by the full-length isoform. The Fas/Fas ligand system has been shown to play a role in a number of human diseases such as AIDS, hepatitis and cancer. It is also assumed that induction of apoptosis through FAS ligand pathway is predominantly involved in anti-viral immune responses.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Apo-1 antigen; Apo-1 Fas; Apo1 antigen; Apoptosis-mediating surface antigen FAS; CD95; Fas (TNF receptor superfamily member); Fas antigen; FASLG receptor; lymphoproliferation; OTTHUMP00000020045; OTTHUMP00000020046; OTTHUMP00000020051; OTTHUMP00000059646; Tumor necrosis factor receptor superfamily member 6
基因别名: AI196731; APO1; APT1; CD95; Fas; lpr; TNFR6; Tnfrsf6
UniProt ID: (Mouse) P25446
Entrez Gene ID: (Mouse) 14102
immunoglobulin production
renal system process
apoptotic process
activation-induced cell death of T cells
inflammatory cell apoptotic process
obsolete transformed cell apoptotic process
immune response
signal transduction
extrinsic apoptotic signaling pathway via death domain receptors
response to toxic substance
gene expression
regulation of gene expression
positive regulation of cell death
B cell mediated immunity
dendrite regeneration
positive regulation of protein homooligomerization
tumor necrosis factor-mediated signaling pathway
regulation of cell proliferation
regulation of apoptotic process
T cell homeostasis
positive regulation of apoptotic process
negative regulation of apoptotic process
positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
negative thymic T cell selection
regulation of lymphocyte differentiation
regulation of myeloid cell differentiation
spleen development
negative regulation of B cell activation
protein homooligomerization
response to glucocorticoid
neuron apoptotic process
cellular response to lithium ion
cellular response to hyperoxia
positive regulation of release of cytochrome c from mitochondria
motor neuron apoptotic process
apoptotic signaling pathway
extrinsic apoptotic signaling pathway
extrinsic apoptotic signaling pathway in absence of ligand
hepatocyte apoptotic process
necroptotic signaling pathway
positive regulation of extrinsic apoptotic signaling pathway in absence of ligand
