Invitrogen

FAT4 Polyclonal Antibody

FAT4 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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FAT4 Antibody (PA5-72970) in IHC (P)

Immunohistochemical analysis of FAT4 in mouse prostate cancer. Samples were incubated with FAT4 polyclonal antibody (Product # PA5-72970) followed by DAB with hematoxylin counterstain.

FAT4 Antibody in Immunohistochemistry (IHC)

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产品信息

PA5-72970

应用

建议稀释比

已发表文章

免疫印迹 (WB)

Assay-Dependent

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免疫组化 (IHC)

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免疫组化（石蜡） (IHC (P))

1:150

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免疫细胞化学 (ICC/IF)

1:100

产品规格

种属反应

Human, Mouse

已发表种属

Human, Mouse

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

A synthetic peptide made to a C-terminal portion of the human FAT4 protein (between residues 4000-4500) [UniProt Q6V0I7]

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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1.0 mg/mL

纯化类型

Antigen affinity chromatography

保存液

PBS

内含物

0.02% sodium azide

保存条件

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

运输条件

Wet ice

AB_2718824

靶标信息

FAT1, FAT2, FAT3 and FAT4 are human homologs of Drosophila Fat, which is involved in tumor suppression and planar cell polarity (PCP). FAT4 undergo the first proteolytic cleavage by Furin and are predicted to undergo the second cleavage by secretase to release intracellular domain (ICD). FAT4 directly interacts with MPDZ/MUPP1 to recruit membrane associated guanylate kinase MPP5/PALS1. FAT4 is involved in the maintenance of PCP and inhibition of cell proliferation.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

Product References

Comparison of the mutation patterns between tumor tissue and cell-free DNA in stage IV gastric cancer.

Aging

Kung CY,Fang WL,Hung YP,Huang KH,Chen MH,Chao Y,Lin SC,Li AF,Lo SS,Wu CW

PA5-72970 was used in Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot to analyze cfDNA and tumor DNA in 56 stage IV GC patients the prediction of mutation in tumor samples, monitoring the mutation pattern of cfDNA.

Fri Feb 10 00:00:00 UTC 2023

Comparison of the mutation patterns between tumor tissue and cell-free DNA in stage IV gastric cancer.

Aging

Kung CY,Fang WL,Hung YP,Huang KH,Chen MH,Chao Y,Lin SC,Li AF,Lo SS,Wu CW

Fri Feb 10 00:00:00 UTC 2023

The TCM Prescription Yi-Fei-Jie-Du-Tang Inhibit Invasive Migration and EMT of Lung Cancer Cells by Activating Autophagy.

Evidence-based complementary and alternative medicine : eCAM

Wang S,Wang Z,Wu Y,Hou C,Dai X,Wang Q,Wu Y,Qian C,Zhang X

PA5-72970 was used in Immunohistochemistry to suggest that the inhibitory effect of YFJDT on EMT in lung cancer tumors is through upregulating FAT4, promoting autophagy, and thus inhibiting EMT in cancer cells.

Wed Feb 16 00:00:00 UTC 2022

The TCM Prescription Yi-Fei-Jie-Du-Tang Inhibit Invasive Migration and EMT of Lung Cancer Cells by Activating Autophagy.

Evidence-based complementary and alternative medicine : eCAM

Wang S,Wang Z,Wu Y,Hou C,Dai X,Wang Q,Wu Y,Qian C,Zhang X

Wed Feb 16 00:00:00 UTC 2022

Tumor suppressive role of mitochondrial sirtuin 4 in induction of G2/M cell cycle arrest and apoptosis in hepatitis B virus-related hepatocellular carcinoma.

Cell death discovery

Huang FY,Wong DK,Seto WK,Mak LY,Cheung TT,Yuen MF

PA5-72970 was used in Western Blotting to investigate the clinical significance and functional role of Sirtuin 4 in hepatitis B virus (HBV)-related hepatocellular carcinoma.

Fri Apr 30 00:00:00 UTC 2021

Tumor suppressive role of mitochondrial sirtuin 4 in induction of G2/M cell cycle arrest and apoptosis in hepatitis B virus-related hepatocellular carcinoma.

Cell death discovery

Huang FY,Wong DK,Seto WK,Mak LY,Cheung TT,Yuen MF

PA5-72970 was used in Western Blotting to investigate the clinical significance and functional role of Sirtuin 4 in hepatitis B virus (HBV)-related hepatocellular carcinoma.

Fri Apr 30 00:00:00 UTC 2021

生物信息学

蛋白别名: Cadherin family member 14; cadherin-related family member 11; FAT tumor suppressor homolog 4; Fat-like cadherin protein FAT-J; hFat4; Protocadherin Fat 4; putative protein product of Nbla00548

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基因别名: 6030410K14Rik; 9430004M15; CDHF14; CDHR11; FAT-J; FAT4; FATJ; HKLLS2; NBLA00548; VMLDS2

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UniProt ID: (Human) Q6V0I7, (Mouse) Q2PZL6

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Entrez Gene ID: (Human) 79633, (Mouse) 329628

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功能

calcium ion binding protein binding cadherin

参与通路