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产品信息
PA5-19056
应用
建议稀释比
已发表文章
产品规格
种属反应
Mouse
已发表种属
Mouse
宿主/亚型
Goat
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic peptide sequence (NSKTKTQYFHQEK) corresponding to the internal amino acids of FBXO32 (aa 70-83).
偶联物
形式
Liquid
浓度
0.5 mg/mL
纯化类型
Ammonium sulfate precipitation
保存液
TBS, pH 7.3, with 0.5% BSA
内含物
0.02% sodium azide
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Wet ice
RRID
AB_10982534
产品详细信息
This antibody is predicted to react with bovine, porcine and rat based on sequence homology.
This antibody is tested in Peptide ELISA: antibody detection limit dilution 16,000.
靶标信息
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs, which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class and contains an F-box domain. This protein is highly expressed during muscle atrophy, whereas mice deficient in this gene were found to be resistant to atrophy. This protein is thus a potential drug target for the treatment of muscle atrophy. Alternative splicing of this gene results in two transcript variants encoding two isoforms of different sizes.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: atrogin 1; Atrogin-1; F-box only protein 32; fbxo25; FLJ32424; MAFbx; MGC108443; MGC137646; MGC33610; Muscle atrophy F-box protein
基因别名: 4833442G10Rik; AI430017; ATROGIN1; Fbxo32; Gm20361; MAFbx
UniProt ID: (Mouse) Q9CPU7
Entrez Gene ID: (Mouse) 67731
