Product References
Oocytes mount a noncanonical DNA damage response involving APC-Cdh1-mediated proteolysis.
The Journal of cell biology
Subramanian GN,Greaney J,Wei Z,Becherel O,Lavin M,Homer HA
37-6600 was used in Western Blotting to find that mouse oocytes deleted of Setx accumulate DNA damage when expose to oxidative stress in vitro and during aging in vivo, after which, surprisingly, undergo G2 arrest.
Mon Apr 06 00:00:00 UTC 2020
Oocytes mount a noncanonical DNA damage response involving APC-Cdh1-mediated proteolysis.
The Journal of cell biology
Subramanian GN,Greaney J,Wei Z,Becherel O,Lavin M,Homer HA
37-6600 was used in Western Blotting to find that mouse oocytes deleted of Setx accumulate DNA damage when expose to oxidative stress in vitro and during aging in vivo, after which, surprisingly, undergo G2 arrest.
Mon Apr 06 00:00:00 UTC 2020
Kaposi's Sarcoma-Associated Herpesvirus Lytic Replication Is Independent of Anaphase-Promoting Complex Activity.
Journal of virology
Elbasani E,Gramolelli S,Günther T,Gabaev I,Grundhoff A,Ojala PM
37-6600 was used in Western Blotting to address whether the oncogenic Kaposi's sarcoma-associated herpesvirus (KSHV) deregulates the activity of APC/C during the lytic replication cycle.
Tue Jun 16 00:00:00 UTC 2020
Kaposi's Sarcoma-Associated Herpesvirus Lytic Replication Is Independent of Anaphase-Promoting Complex Activity.
Journal of virology
Elbasani E,Gramolelli S,Günther T,Gabaev I,Grundhoff A,Ojala PM
37-6600 was used in Western Blotting to address whether the oncogenic Kaposi's sarcoma-associated herpesvirus (KSHV) deregulates the activity of APC/C during the lytic replication cycle.
Tue Jun 16 00:00:00 UTC 2020
Excessive E2F Transcription in Single Cancer Cells Precludes Transient Cell-Cycle Exit after DNA Damage.
Cell reports
Segeren HA,van Rijnberk LM,Moreno E,Riemers FM,van Liere EA,Yuan R,Wubbolts R,de Bruin A,Westendorp B
37-6600 was used in Western Blotting to study neoplastic cell expression of E2F-dependent transcription within human cancer biopsy specimens.
Tue Dec 01 00:00:00 UTC 2020
Altered G1 signaling order and commitment point in cells proliferating without CDK4/6 activity.
Nature communications
Liu C,Konagaya Y,Chung M,Daigh LH,Fan Y,Yang HW,Terai K,Matsuda M,Meyer T
37-6600 was used in Western Blotting to delineate sequential molecular events in the CDK2-initiated path that are distinct from the CDK4/6-initiated path.
Tue Oct 20 00:00:00 UTC 2020
EMI1 switches from being a substrate to an inhibitor of APC/CCDH1 to start the cell cycle.
Nature
Cappell SD,Mark KG,Garbett D,Pack LR,Rape M,Meyer T
37-6600 was used in Immunocytochemistry-immunoflourescence to elucidate the role of early mitotic inhibitor 1 (EMI1) as both a substrate and an inhibitor of anaphase-promoting complex (APC/CCDH1) in cell-cycle commitment.
Fri Jun 01 00:00:00 UTC 2018
EMI1 switches from being a substrate to an inhibitor of APC/CCDH1 to start the cell cycle.
Nature
Cappell SD,Mark KG,Garbett D,Pack LR,Rape M,Meyer T
37-6600 was used in Immunocytochemistry-immunoflourescence to elucidate the role of early mitotic inhibitor 1 (EMI1) as both a substrate and an inhibitor of anaphase-promoting complex (APC/CCDH1) in cell-cycle commitment.
Fri Jun 01 00:00:00 UTC 2018
EMI1 switches from being a substrate to an inhibitor of APC/CCDH1 to start the cell cycle.
Nature
Cappell SD,Mark KG,Garbett D,Pack LR,Rape M,Meyer T
37-6600 was used in Immunocytochemistry-immunoflourescence to elucidate the role of early mitotic inhibitor 1 (EMI1) as both a substrate and an inhibitor of anaphase-promoting complex (APC/CCDH1) in cell-cycle commitment.
Fri Jun 01 00:00:00 UTC 2018
Progression through mitosis promotes PARP inhibitor-induced cytotoxicity in homologous recombination-deficient cancer cells.
Nature communications
Schoonen PM,Talens F,Stok C,Gogola E,Heijink AM,Bouwman P,Foijer F,Tarsounas M,Blatter S,Jonkers J,Rottenberg S,van Vugt MATM
37-6600 was used in Western Blotting to examine the cytotoxic effects of PARP inhibition, and its therapeutic potential for the treatment of homologous recombination-deficient tumours.
Mon Jul 17 00:00:00 UTC 2017
New origin firing is inhibited by APC/CCdh1 activation in S-phase after severe replication stress.
Nucleic acids research
Ercilla A,Llopis A,Feu S,Aranda S,Ernfors P,Freire R,Agell N
37-6600 was used in western blot to study APC/C(Cdh1) function
Thu Jun 02 00:00:00 UTC 2016
New origin firing is inhibited by APC/CCdh1 activation in S-phase after severe replication stress.
Nucleic acids research
Ercilla A,Llopis A,Feu S,Aranda S,Ernfors P,Freire R,Agell N
37-6600 was used in western blot to study APC/C(Cdh1) function
Thu Jun 02 00:00:00 UTC 2016
Feedback regulation between atypical E2Fs and APC/CCdh1 coordinates cell cycle progression.
EMBO reports
Boekhout M,Yuan R,Wondergem AP,Segeren HA,van Liere EA,Awol N,Jansen I,Wolthuis RM,de Bruin A,Westendorp B
Published figure using FBXO5 monoclonal antibody (Product # 37-6600) in Western Blot
Tue Mar 01 00:00:00 UTC 2016
Hypersensitivity to DNA damage in antephase as a safeguard for genome stability.
Nature communications
Feringa FM,Krenning L,Koch A,van den Berg J,van den Broek B,Jalink K,Medema RH
37-6600 was used in western blot to describe a novel irreversible DNA-damage response in antephase
Fri Aug 26 00:00:00 UTC 2016
MASTL promotes cyclin B1 destruction by enforcing Cdc20-independent binding of cyclin B1 to the APC/C.
Biology open
Voets E,Wolthuis R
37-6600 was used in western blot to study the effect of MASTL on cyclin B1 degradation and its mechanism
Fri Mar 06 00:00:00 UTC 2015
Centriole maturation requires regulated Plk1 activity during two consecutive cell cycles.
The Journal of cell biology
Kong D,Farmer V,Shukla A,James J,Gruskin R,Kiriyama S,Loncarek J
37-6600 was used in Western Blotting to study the role of Plk1 activity in the gradual, biochemical and structural maturation of centrioles.
Mon Sep 29 00:00:00 UTC 2014
Human papillomavirus type 16 E7 oncoprotein inhibits the anaphase promoting complex/cyclosome activity by dysregulating EMI1 expression in mitosis.
Virology
Yu Y,Munger K
37-6600 was used in western blot to study the effect of human papillomavirus type 16 E7 oncoprotein on the anaphase promoting complex/cyclosome and its mechanism
Fri Nov 01 00:00:00 UTC 2013
Selective enhancing effect of early mitotic inhibitor 1 (Emi1) depletion on the sensitivity of doxorubicin or X-ray treatment in human cancer cells.
The Journal of biological chemistry
Shimizu N,Nakajima NI,Tsunematsu T,Ogawa I,Kawai H,Hirayama R,Fujimori A,Yamada A,Okayasu R,Ishimaru N,Takata T,Kudo Y
Fri Jun 14 00:00:00 UTC 2013
The anaphase-promoting complex or cyclosome supports cell survival in response to endoplasmic reticulum stress.
PloS one
Chen M,Gutierrez GJ,Ronai ZA
37-6600 was used in western blot to investigate the regulation and function of APC/C(Cdh) in non-genotoxic stress responses.
Mon Sep 10 00:00:00 UTC 2012
Regulation of the action of early mitotic inhibitor 1 on the anaphase-promoting complex/cyclosome by cyclin-dependent kinases.
The Journal of biological chemistry
Moshe Y,Bar-On O,Ganoth D,Hershko A
37-6600 was used in western blot to identify mechanisms other than degradation of Emi1, which release APC/C and promote entry into mitosis.
Fri May 13 00:00:00 UTC 2011
Substrate degradation by the anaphase promoting complex occurs during mitotic slippage.
Cell cycle (Georgetown, Tex.)
Lee J,Kim JA,Margolis RL,Fotedar R
Sat May 01 00:00:00 UTC 2010
Regulation of APC/C (Cdh1) ubiquitin ligase in differentiation of human embryonic stem cells.
Cell cycle (Georgetown, Tex.)
Bar-On O,Shapira M,Skorecki K,Hershko A,Hershko DD
37-6600 was used in Western Blotting to study the activity of APC/C (Cadh1) during the differentiation process of human embryonic stem cells.
Sat May 15 00:00:00 UTC 2010
DNA damage triggers p21WAF1-dependent Emi1 down-regulation that maintains G2 arrest.
Molecular biology of the cell
Lee J,Kim JA,Barbier V,Fotedar A,Fotedar R
37-6600 was used in western blot to assess the role of p21(WAF1) in G2-M phase checkpoint control and in prevention of polyploidy after DNA damage
Wed Apr 01 00:00:00 UTC 2009
