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FBXW11 Antibody (PA5-100524) in IHC (P)
Immunohistochemistry analysis of FBXW11 in human gastric cancer. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. Samples were incubated with FBXW11 polyclonal antibody (Product # PA5-100524) using a dilution of 1:100 (4°C overnight) followed by HRP conjugated anti-Rabbit secondary antibody.
产品信息
PA5-100524
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthesized peptide derived from human FBXW11(Accession Q9UKB1), corresponding to amino acid residues F503-R542.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Affinity chromatography
保存液
PBS, pH 7.4, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice
RRID
AB_2850033
产品详细信息
Antibody detects endogenous levels of total FBXW11.
靶标信息
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbws class and, in addition to an F-box, contains multiple WD40 repeats. This gene contains at least 14 exons, and its alternative splicing generates 3 transcript variants diverging at the presence/absence of two alternate exons.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: beta-transducin repeat-containing protein 2; F-box and WD repeats protein beta-TrCP2; F-box and WD-40 domain protein 11; F-box and WD-40 domain protein 1B; F-box protein Fbw1b; F-box/WD repeat-containing protein 11; F-box/WD repeat-containing protein 1B; Homologous to Slimb protein; HOS
基因别名: 2310065A07Rik; AA536858; BTRC2; BTRCP2; Fbw11; FBW1B; FBXW11; FBXW1B; HOS; KIAA0696
UniProt ID: (Human) Q9UKB1, (Mouse) Q5SRY7
Entrez Gene ID: (Human) 23291, (Mouse) 103583, (Rat) 303024
protein polyubiquitination
protein dephosphorylation
cell cycle
Wnt signaling pathway
protein ubiquitination
SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
protein destabilization
negative regulation of NF-kappaB import into nucleus
positive regulation of circadian rhythm
proteasome-mediated ubiquitin-dependent protein catabolic process
positive regulation of proteolysis
negative regulation of transcription, DNA-templated
positive regulation of transcription, DNA-templated
rhythmic process
G2/M transition of mitotic cell cycle
stimulatory C-type lectin receptor signaling pathway
NIK/NF-kappaB signaling
Fc-epsilon receptor signaling pathway
T cell receptor signaling pathway
stress-activated MAPK cascade
