Invitrogen

FDPS Polyclonal Antibody

FDPS Antibody in Immunocytochemistry (ICC/IF)

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FDPS Antibody (PA5-28228) in ICC/IF

Immunocytochemistry-Immunofluorescence analysis of FDPS was performed in HeLa cells fixed in ice-cold MeOH for 5 min. Green: FDPS Polyclonal Antibody (Product # PA5-28228) diluted at 1:500. Blue: Hoechst 33342 staining. Scale bar = 10 µm.

FDPS Antibody in Immunohistochemistry (Paraffin) (IHC (P))

FDPS Antibody in Western Blot, Immunohistochemistry (WB, IHC)

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产品信息

PA5-28228

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1:500-1:3,000

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免疫组化 (IHC)

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免疫组化（石蜡） (IHC (P))

1:100-1:1,000

免疫细胞化学 (ICC/IF)

1:100-1:1,000

产品规格

种属反应

Human, Mouse, Rat

已发表种属

Human, Mouse

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

Recombinant fragment corresponding to a region within amino acids 43 and 381 of Human FDPS

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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1.35 mg/mL

纯化类型

Antigen affinity chromatography

保存液

PBS, pH 7, with 20% glycerol

内含物

0.025% ProClin 300

保存条件

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

运输条件

Wet ice

AB_2545704

产品详细信息

Recommended positive controls: A549, H1299, HCT116, Mouse brain, rat liver.

Predicted reactivity: Mouse (89%), Rat (89%), Pig (89%), Bovine (91%).

Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

靶标信息

The isoprene biosynthetic pathway supply the cell with cholesterol, ubiquinone, and various nonsterol metabolites. The farnesylpyrophosphate synthetase enzyme catalyzes the formation of geranyl and farnesylpyrophosphate from isopentenylpyrophosphate and dimethylallyl pyrophosphate. Analysis of FDPS activity and protein in rat liver, accompanied by immunofluorescence and immunoelectron microscopy studies, demonstrated that FDPS is predominantly localized in peroxisomes. 1 Liver tissue from patients with the peroxisomal deficiency diseases Zellweger syndrome and neonatal adrenoleukodystrophy exhibit diminished activities of FDPS and subsequent isoprenoid synthesis.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

Product References

Astrocyte-oligodendrocyte interaction regulates central nervous system regeneration.

Nature communications

Molina-Gonzalez I,Holloway RK,Jiwaji Z,Dando O,Kent SA,Emelianova K,Lloyd AF,Forbes LH,Mahmood A,Skripuletz T,Gudi V,Febery JA,Johnson JA,Fowler JH,Kuhlmann T,Williams A,Chandran S,Stangel M,Howden AJM,Hardingham GE,Miron VE

PA5-28228 was used in Immunohistochemistry-immunofluorescence to identify that astrocyte-oligodendrocyte interaction regulates remyelination, and reveal a drug strategy for central nervous system regeneration centred on targeting this interaction.

Thu Jun 08 00:00:00 UTC 2023

Integrating Proteomes for Lung Tissues and Lavage Reveals Pathways That Link Responses in Allergen-Challenged Mice.

ACS omega

Mahood TH,Pascoe CD,Karakach TK,Jha A,Basu S,Ezzati P,Spicer V,Mookherjee N,Halayko AJ

PA5-28228 was used in Western Blot to study proteomic integration as a result of intracellular and extracellular processes.

Tue Jan 19 00:00:00 UTC 2021

Integrating Proteomes for Lung Tissues and Lavage Reveals Pathways That Link Responses in Allergen-Challenged Mice.

ACS omega

Mahood TH,Pascoe CD,Karakach TK,Jha A,Basu S,Ezzati P,Spicer V,Mookherjee N,Halayko AJ

PA5-28228 was used in Western Blot to study proteomic integration as a result of intracellular and extracellular processes.

Tue Jan 19 00:00:00 UTC 2021

Regeneration of Cochlear Synapses by Systemic Administration of a Bisphosphonate.

Frontiers in molecular neuroscience

Seist R,Tong M,Landegger LD,Vasilijic S,Hyakusoku H,Katsumi S,McKenna CE,Edge ASB,Stankovic KM

PA5-28228 was used in Immunohistochemistry to show that systemic administration of a bisphosphonate to mice 24 h after synaptopathic noise exposure regenerated synapses between inner hair cells and SGNs and restored cochlear function.

Fri Dec 02 00:00:00 UTC 2022

FDPS promotes glioma growth and macrophage recruitment by regulating CCL20 via Wnt/β-catenin signalling pathway.

Journal of cellular and molecular medicine

Chen Z,Chen G,Zhao H

PA5-28228 was used in Western Blotting to show that enhancement in FDPS level is observed in glioma tissues and associate with poor prognosis, contributed to tumour growth.

Sat Aug 01 00:00:00 UTC 2020

FDPS promotes glioma growth and macrophage recruitment by regulating CCL20 via Wnt/β-catenin signalling pathway.

Journal of cellular and molecular medicine

Chen Z,Chen G,Zhao H

PA5-28228 was used in Western Blotting to show that enhancement in FDPS level is observed in glioma tissues and associate with poor prognosis, contributed to tumour growth.

Sat Aug 01 00:00:00 UTC 2020

FDPS promotes glioma growth and macrophage recruitment by regulating CCL20 via Wnt/β-catenin signalling pathway.

Journal of cellular and molecular medicine

Chen Z,Chen G,Zhao H

PA5-28228 was used in Western Blotting to show that enhancement in FDPS level is observed in glioma tissues and associate with poor prognosis, contributed to tumour growth.

Sat Aug 01 00:00:00 UTC 2020

Butyrophilin 3A/CD277-Dependent Activation of Human γδ T Cells: Accessory Cell Capacity of Distinct Leukocyte Populations.

Journal of immunology (Baltimore, Md. : 1950)

Nerdal PT,Peters C,Oberg HH,Zlatev H,Lettau M,Quabius ES,Sousa S,Gonnermann D,Auriola S,Olive D,Määttä J,Janssen O,Kabelitz D

PA528228 was used in western blot to analyze the capacity of monocytes, neutrophils, and CD4 T cells to serve as accessory cells for gamma delta T cell activation

Sat Oct 15 00:00:00 UTC 2016

生物信息学

蛋白别名: (2E,6E)-farnesyl diphosphate synthase; Cholesterol-regulated 39 kDa protein; CR 39; Dimethylallyltranstransferase; Farnesyl diphosphate synthase; farnesyl diphosphate synthase (farnesyl pyrophosphate synthetase, dimethylallyltranstransferase, geranyltranstransferase); farnesyl diphosphate synthetase; Farnesyl pyrophosphate synthase; farnesyl pyrophosphate synthetase; farnesyl pyrophosphate synthetase, dimethylallyltranstransferase, geranyltranstransferase; FPP synthase; FPP synthetase; FPS; Geranyltranstransferase; testis-specific farnesyl pyrophosphate synthetase

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基因别名: 6030492I17Rik; Ac2-125; AI256750; FDPS; Fdpsl1; FPPS; FPS; KIAA1293; mKIAA1293; POROK9

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UniProt ID: (Human) P14324, (Rat) P05369, (Mouse) Q920E5

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Entrez Gene ID: (Human) 2224, (Rat) 83791, (Mouse) 110196

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功能

dimethylallyltranstransferase activity geranyltranstransferase activity poly(A) RNA binding metal ion binding farnesyltranstransferase activity transferase activity

参与通路