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FEV Antibody (PA5-98805) in ICC/IF
Immunofluorescent analysis of FEV in Hela cells using a FEV polyclonal antibody (Product # PA5-98805) at a dilution of 1:100. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated Goat Anti-Rabbit IgG(H+L). Cells were counter-stained with DAPI.
产品信息
PA5-98805
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant Human Protein FEV protein (1-97AA)
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Protein G
保存液
PBS, pH 7.4, with 50% glycerol
内含物
0.03% ProClin 300
保存条件
-20°C or -80°C if preferred
运输条件
Wet ice
RRID
AB_2813418
靶标信息
This gene belongs to the ETS transcription factor family. ETS family members have a highly conserved 85-amino acid ETS domain that binds purine-rich DNA sequences. The alanine-rich C-terminus of this gene indicates that it may act as a transcription repressor. This gene is exclusively expressed in neurons of the central serotonin (5-HT) system, a system implicated in the pathogeny of such psychiatric diseases as depression, anxiety, and eating disorders. In some types of Ewing tumors, this gene is fused to the Ewing sarcoma (EWS) gene following chromosome translocations.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: ETS domain transcription factor Pet-1; FEV (ETS oncogene family); Fifth Ewing variant protein; PC12 ETS domain-containing transcription factor 1; PC12 ETS factor 1; pet-1; Protein FEV
基因别名: FEV; HSRNAFEV; PET-1; PET1
UniProt ID: (Human) Q99581, (Rat) O70132
Entrez Gene ID: (Human) 54738, (Rat) 246271
regulation of transcription from RNA polymerase II promoter
transcription from RNA polymerase II promoter
positive regulation of gene expression
cell differentiation
neuron maturation
neuron fate specification
negative regulation of nucleic acid-templated transcription
positive regulation of transcription, DNA-templated
