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FGF23 Antibody (500-P319-1MG) in WB
Western Blot: To detect Human FGF-23 by Western Blot analysis FGF23 Polyclonal Antibody (Product # 500-P319-1MG) can be used at a concentration of 0.1-0.2 µg/mL. When used in conjunction with compatible secondary reagents, the detection limit for Recombinant Human FGF-23 is 1.5-3.0 ng/lane, under either reducing or non-reducing conditions.
产品信息
500-P319-1MG
产品规格
种属反应
Human
宿主/亚型
Rabbit
分类
Polyclonal
类型
Antibody
抗原
E.coli-derived, 25.5kDa Recombinant Human FGF-2
偶联物
形式
Lyophilized
纯化类型
Affinity chromatography
保存液
PBS
内含物
no preservative
保存条件
-20°C
运输条件
Ambient
RRID
AB_2942228
产品详细信息
AA Sequence of recombinant protein: MYPNASPLLG SSWGGLIHLY TATARNSYHL QIHKNGHVDG APHQTIYSAL MIRSEDAGFV VITGVMSRRY LCMDFRGNIF GSHYFDPENC RFQHQTLENG YDVYHSPQYH FLVSLGRAKR AFLPGMNPPP YSQFLSRRNE IPLIHFNTPI PRRHTRSAED DSERDPLNVL KPRARMTPAP ASCSQELPSA EDNSPMASDP LGVVRGGRVN THAGGTGPEG CRPFAKFI
Preparation: Produced from sera of rabbits immunized with highly pure Recombinant Human FGF-23. Anti-Human FGF-23-specific antibody was purified by affinity chromatography employing an immobilized Human FGF-23 matrix.
Sandwich ELISA: To detect Human FGF-23 by sandwich ELISA (using 100 µL/well), a concentration of 0.5-2.0 µg/mL of this antibody is required. This antigen affinity purified antibody, in conjunction with PeproTech Biotinylated Anti-Human FGF-23 (500-P319BT) as a detection antibody, allows the detection of at least 2000-4000 pg/mL of Recombinant Human FGF-23.
Western Blot: To detect Human FGF-23 by Western Blot analysis this antibody can be used at a concentration of 0.1-0.2 µg/mL. When used in conjunction with compatible secondary reagents, the detection limit for Recombinant Human FGF-23 is 1.5-3.0 ng/lane, under either reducing or non-reducing conditions.
靶标信息
The protein encoded by this gene is a member of the fibroblast growth factor family. FGF family members possess broad mitogenic and cell survival activities and are involved in a variety of biological processes including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. The product of this gene inhibits renal tubular phosphate transport. This gene was identified by its mutations associated with autosomal dominant hypophosphatemic rickets, an inherited phosphate wasting disorder. Abnormally high level expression of this gene was found in oncogenic hypophosphatemic osteomalacia, a phenotypically similar disease caused by abnormal phosphate metabolism. Mutations in this gene have also been shown to cause familial tumoral calcinosis with hyperphosphatemia.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: FGF; FGF-23; Fibroblast growth factor; Fibroblast growth factor 23; Phosphatonin; tumor-derived hypophosphatemia inducing factor; Tumor-derived hypophosphatemia-inducing factor
基因别名: ADHR; FGF23; FGFN; HPDR2; HYPF; PHPTC; UNQ3027/PRO9828
UniProt ID: (Human) Q9GZV9
Entrez Gene ID: (Human) 8074
MAPK cascade
fibroblast growth factor receptor signaling pathway
regulation of phosphate transport
positive regulation of vitamin D 24-hydroxylase activity
regulation of phosphatidylinositol 3-kinase signaling
peptidyl-tyrosine phosphorylation
cell differentiation
negative regulation of bone mineralization
cellular phosphate ion homeostasis
response to magnesium ion
phosphatidylinositol-3-phosphate biosynthetic process
vitamin D catabolic process
positive regulation of GTPase activity
cellular response to leptin stimulus
negative regulation of osteoblast differentiation
positive regulation of transcription, DNA-templated
phosphatidylinositol phosphorylation
negative regulation of hormone secretion
phosphatidylinositol-mediated signaling
phosphate ion homeostasis
positive regulation of ERK1 and ERK2 cascade
cellular response to vitamin D
cellular response to interleukin-6
cellular response to parathyroid hormone stimulus
positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway
response to sodium phosphate
