Invitrogen

FGFBP1 Polyclonal Antibody

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FGFBP1 Antibody (PA5-96685) in WB

Western blot analysis of FGFBP1 in extracts of various cell lines. Samples were incubated with FGFBP1 Polyclonal antibody (Product # PA5-96685) using a dilution of 1:1,000, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 30s.

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产品信息

PA5-96685

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1:500-1:2,000

酶联免疫吸附实验 (ELISA)

1 µg/mL

产品规格

种属反应

Human, Mouse, Rat

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

Recombinant fusion protein containing a sequence corresponding to amino acids 24-234 of human FGFBP1 (NP_0051211)

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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1.45 mg/mL

纯化类型

Affinity Chromatography

保存液

PBS, pH 7.3, with 50% glycerol

内含物

0.02% sodium azide

保存条件

-20° C, Avoid Freeze/Thaw Cycles

运输条件

Wet ice

AB_2808487

产品详细信息

Immunogen sequence: KKKVKNGLHS KVVSEQKDTL GNTQIKQKSR PGNKGKFVTK DQANCRWAAT EQEEGISLKV ECTQLDHEFS CVFAGNPTSC LKLKDERVYW KQVARNLRSQ KDICRYSKTA VKTRVCRKDF PESSLKLVSS TLFGNTKPRK EKTEMSPREH IKGKETTPSS LAVTQTMATK APECVEDPDM ANQRKTALEF CGETWSSLCT FFLSIVQDTS C; Positive Samples: A-549, HepG2, NIH/3T3, Mouse kidney, Mouse lung, Rat brain; Cellular Location: Cell membrane, Peripheral membrane protein, extracellular space

靶标信息

FGFBP1 encodes a secreted fibroblast growth factor carrier protein. The encoded protein plays a critical role in cell proliferation, differentiation and migration by binding to fibroblast growth factors and potentiating their biological effects on target cells. The encoded protein may also play a role in tumor growth as an angiogenic switch molecule, and expression of this gene has been associated with several types of cancer including pancreatic and colorectal adenocarcinoma. A pseudogene of this gene is also located on the short arm of chromosome 4.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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引用该产品

生物信息学

蛋白别名: 17 kDa HBGF-binding protein; 17 kDa heparin-binding growth factor-binding protein; FGF-binding protein 1; FGF-BP; FGF-BP1; FGFBP-1; Fibroblast growth factor-binding protein 1; growth factor binding protein-1; growth factor-binding protein 1; heparin-binding growth factor binding protein

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基因别名: FGF-BP; FGF-BP1; FGFBP; FGFBP-1; FGFBP1; HBP17

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UniProt ID: (Human) Q14512, (Mouse) O70514, (Rat) Q9QY10

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Entrez Gene ID: (Human) 9982, (Mouse) 14181, (Rat) 64535

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功能

protein binding heparin binding fibroblast growth factor binding growth factor binding

参与通路

positive regulation of defense response to virus by host cell-cell signaling positive regulation of cell proliferation positive regulation of fibroblast growth factor receptor signaling pathway mitophagy in response to mitochondrial depolarization signal transduction negative regulation of cell proliferation fibroblast growth factor receptor signaling pathway xenophagy