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FGR Antibody (703189) in WB
Western blot analysis was performed on Membrane enriched extracts (30 µg lysate) of Daudi (Lane 1) Raji (Lane 2), Ramos (Lane 3), human PBMCs (Lane 4), HL-60 (Lane 5) and HL-60 treated with Retinoic Acid (1µM, 48 hr) (Lane 6). The blot was probed with Anti-FGR Recombinant Rabbit Monoclonal Antibody (Product # 703189, 1:500 dilution) and detected by chemiluminescence using Goat anti-Rabbit IgG (Heavy Chain) Superclonal™ Secondary Antibody, HRP conjugate (Product # A27036, 0.25 µg/mL, 1:4000 dilution). A 60 kDa band corresponding to FGR (tyr... View More
产品信息
703189
产品规格
种属反应
Human
已发表种属
Insect
宿主/亚型
Rabbit
/ IgG
Expression System
Expi293
分类
Recombinant Monoclonal
类型
Antibody
克隆号
13H37L5
抗原
Protein corresponding to human FGR [aa1-aa76]
偶联物
形式
Liquid
浓度
0.5 mg/mL
纯化类型
Protein A
保存液
PBS, pH 7.4
内含物
0.09% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_2734808
产品详细信息
This antibody is predicted to react with Monkey, Pig, Horse.
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire.
靶标信息
FGR is a SRC-related kinase present in hematopoietic cells. FGR signals within multiple pathways including within the integrin pathway and downstream of chemokine and cytokine receptors. This protein contains N-terminal sites for myristylation and palmitoylation, a PTK domain, and SH2 and SH3 domains which are involved in mediating protein-protein interactions with phosphotyrosine-containing and proline-rich motifs, respectively. It localizes to plasma membrane ruffles, and functions as a negative regulator of cell migration and adhesion triggered by the beta-2 integrin signal transduction pathway. Infection with Epstein-Barr virus results in the overexpression of this protein.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: c-fgr protooncogene; c-src-2 proto-oncogene; EC 2.7.10.2; feline Gardner-Rasheed sarcoma viral oncogene homolog; FGR protein; FLJ43153; Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog; MGC75096; OTTHUMP00000003603; OTTHUMP00000003604; p55-c-fgr protein; p55-Fgr; p58-Fgr; p58c-Fgr; Proto-oncogene c-Fgr; proto-oncogene tyrosine-protein kinase FGR; Tyrosine-protein kinase Fgr; v-fgr feline Gardner-Rasheed sarcoma viral oncogene homolog
基因别名: c-fgr; c-src2; FGR; p55-Fgr; p55c-fgr; p58-Fgr; p58c-fgr; SRC2
UniProt ID: (Human) P09769
Entrez Gene ID: (Human) 2268
immune response-regulating cell surface receptor signaling pathway
protein phosphorylation
transmembrane receptor protein tyrosine kinase signaling pathway
integrin-mediated signaling pathway
regulation of cell shape
response to virus
positive regulation of phosphatidylinositol 3-kinase signaling
cell migration
peptidyl-tyrosine phosphorylation
cell differentiation
positive regulation of cell migration
peptidyl-tyrosine autophosphorylation
Fc-gamma receptor signaling pathway involved in phagocytosis
regulation of cell proliferation
positive regulation of mast cell degranulation
positive regulation of phosphatidylinositol 3-kinase activity
innate immune response
regulation of innate immune response
regulation of protein kinase activity
protein autophosphorylation
positive regulation of cytokine secretion
regulation of phagocytosis
defense response to Gram-positive bacterium
