Invitrogen

FIG4 Polyclonal Antibody

图: 1 / 1

FIG4 Antibody (PA5-120353) in WB

Western blot analysis of FIG4 in extracts of various cell lines. Samples were incubated with FIG4 Polyclonal antibody (Product # PA5-120353) using a dilution of 1:1,000, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 30s.

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产品信息

PA5-120353

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1:200-1:2,000

酶联免疫吸附实验 (ELISA)

1 µg/mL

产品规格

种属反应

Human, Mouse

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

Recombinant fusion protein containing a sequence corresponding to amino acids 608-907 of human FIG4 (NP_055660.1).

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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1.29 mg/mL

纯化类型

Affinity Chromatography

保存液

PBS, pH 7.3, with 50% glycerol

内含物

0.01% thimerosal

保存条件

-20° C, Avoid Freeze/Thaw Cycles

运输条件

Wet ice

AB_2913925

产品详细信息

Positive test controls include: U-251MG, HT-29, Jukat, HeLa, Mouse liver, Mouse spleen. The target is usually found in the following locations: Endosome membrane.

Immunogen sequence: WELPTDFYLH HKNTMRLLPT RRSYTYWWTP EVIKHLPLPY DEVICAVNLK KLIVKKFHKY EEEIDIHNEF FRPYELSSFD DTFCLAMTSS ARDFMPKTVG IDPSPFTVRK PDETGKSVLG NKSNREEAVL QRKTAASAPP PPSEEAVSSS SEDDSGTDRE EEGSVSQRST PVKMTDAGDS AKVTENVVQP MKELYGINLS DGLSEEDFSI YSRFVQLGQS QHKQDKNSQQ PCSRCSDGVI KLTPISAFSQ DNIYEVQPPR VDRKSTEIFQ AHIQASQGIM QPLGKEDSSM YREYIRNRYL

靶标信息

The protein encoded by this gene belongs to the SAC domain-containing protein gene family. The SAC domain, approximately 400 amino acids in length and consisting of seven conserved motifs, has been shown to possess phosphoinositide phosphatase activity. The yeast homolog, Sac1p, is involved in the regulation of various phosphoinositides, and affects diverse cellular functions such as actin cytoskeleton organization, Golgi function, and maintenance of vacuole morphology. Membrane-bound phosphoinositides function as signaling molecules and play a key role in vesicle trafficking in eukaryotic cells. Mutations in this gene have been associated with Charcot-Marie-Tooth disease, type 4J.

⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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生物信息学

蛋白别名: FIG4 homolog, SAC domain containing lipid phosphatase; FIG4 homolog, SAC1 domain containing lipid phosphatase; FIG4 homolog, SAC1 lipid phosphatase domain containing; Phosphatidylinositol 3,5-bisphosphate 5-phosphatase; Polyphosphoinositide phosphatase; RP1-249I4.1; Sac domain-containing inositol phosphatase 3; SAC domain-containing protein 3; Serine-protein phosphatase FIG4

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基因别名: A530089I17Rik; AI326867; ALS11; BTOP; CMT4J; dJ249I4.1; FIG4; KIAA0274; SAC3; YVS

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UniProt ID: (Human) Q92562, (Mouse) Q91WF7

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Entrez Gene ID: (Human) 9896, (Mouse) 103199

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功能