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产品信息
PA5-68477
产品规格
种属反应
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthesized peptide derived from human FIG4 [aa 341-390].
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
affinity chromatography
保存液
PBS, pH 7.4, with 50% glycerol, 0.5% BSA
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2691672
靶标信息
The protein encoded by this gene belongs to the SAC domain-containing protein gene family. The SAC domain, approximately 400 amino acids in length and consisting of seven conserved motifs, has been shown to possess phosphoinositide phosphatase activity. The yeast homolog, Sac1p, is involved in the regulation of various phosphoinositides, and affects diverse cellular functions such as actin cytoskeleton organization, Golgi function, and maintenance of vacuole morphology. Membrane-bound phosphoinositides function as signaling molecules and play a key role in vesicle trafficking in eukaryotic cells. Mutations in this gene have been associated with Charcot-Marie-Tooth disease, type 4J.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: FIG4 homolog, SAC domain containing lipid phosphatase; FIG4 homolog, SAC1 domain containing lipid phosphatase; FIG4 homolog, SAC1 lipid phosphatase domain containing; Phosphatidylinositol 3,5-bisphosphate 5-phosphatase; Polyphosphoinositide phosphatase; RP1-249I4.1; Sac domain-containing inositol phosphatase 3; SAC domain-containing protein 3; Serine-protein phosphatase FIG4
基因别名: A530089I17Rik; AI326867; ALS11; BTOP; CMT4J; dJ249I4.1; FIG4; KIAA0274; SAC3; YVS
UniProt ID: (Human) Q92562, (Mouse) Q91WF7
Entrez Gene ID: (Human) 9896, (Mouse) 103199
phosphatidylinositol-3-phosphatase activity
protein binding
phosphatidylinositol-4-phosphate phosphatase activity
phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity
protein tyrosine/serine/threonine phosphatase activity
protein tyrosine/threonine phosphatase activity
JUN kinase phosphatase activity
phosphohistidine phosphatase activity
inositol bisphosphate phosphatase activity
hydrolase activity
MAP kinase tyrosine/serine/threonine phosphatase activity
inositol-1,3,4-trisphosphate 4-phosphatase activity
NADP phosphatase activity
transmembrane receptor protein phosphatase activity
inositol-1,3,4,5,6-pentakisphosphate 3-phosphatase activity
inositol-1,4,5,6-tetrakisphosphate 6-phosphatase activity
inositol-4,5-bisphosphate 5-phosphatase activity
phosphatidylinositol bisphosphate phosphatase activity
phosphoric ester hydrolase activity
5-amino-6-(5-phosphoribitylamino)uracil phosphatase activity
phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity
inositol phosphate phosphatase activity
inositol-1,3,4,5,6-pentakisphosphate 1-phosphatase activity
inositol-3,4-bisphosphate 4-phosphatase activity
inositol-1,3,4-trisphosphate 1-phosphatase activity
inositol-1,3,4,6-tetrakisphosphate 6-phosphatase activity
inositol-1,3,4,6-tetrakisphosphate 1-phosphatase activity
phosphatidylinositol-1,4,5-trisphosphate 5-phosphatase activity
IDP phosphatase activity
phosphatase
phosphatidylinositol biosynthetic process
vacuole organization
locomotory behavior
positive regulation of neuron projection development
dephosphorylation
negative regulation of myelination
myelin assembly
phosphatidylinositol-3-phosphate biosynthetic process
pigmentation
neuron development
phosphatidylinositol metabolic process
