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FIP200 Antibody (PA5-99972) in IHC (P)
Immunohistochemistry analysis of FIP200 in human normal tissues adjacent to colorectal cancer. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. Samples were incubated with FIP200 polyclonal antibody (Product # PA5-99972) using a dilution of 1:100 (4°C overnight) followed by HRP conjugated anti-Rabbit secondary antibody.
产品信息
PA5-99972
产品规格
种属反应
Human,
Mouse,
Non-human primate,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthesized peptide derived from human RB1CC1(Accession Q8TDY2), corresponding to amino acid residues N1517-A1567.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Affinity chromatography
保存液
PBS, pH 7.4, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice
RRID
AB_2818905
产品详细信息
Antibody detects endogenous levels of total RB1CC1.
靶标信息
The protein encoded by this gene interacts with signaling pathways to coordinately regulate cell growth, cell proliferation, apoptosis, autophagy, and cell migration. This tumor suppressor also enhances retinoblastoma 1 gene expression in cancer cells. Alternative splicing results in multiple transcript variants encoding distinct isoforms.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: 200 kDa FAK family kinase-interacting protein; coiled coil forming protein 1; Coiled-coil-forming protein 1; FAK family kinase-interacting protein of 200 kDa; FIP200; LaXp180; phosphatase 1, regulatory subunit 131; RB1-inducible coiled-coil 1; RB1-inducible coiled-coil protein 1
基因别名: 2900055E04Rik; 5930404L04Rik; ATG17; CC1; FIP200; KIAA0203; LaXp180; PPP1R131; RB1CC1; RBICC
UniProt ID: (Human) Q8TDY2, (Mouse) Q9ESK9
Entrez Gene ID: (Human) 9821, (Mouse) 12421, (Rat) 312927
autophagosome assembly
liver development
positive regulation of protein phosphorylation
transcription, DNA-templated
regulation of transcription, DNA-templated
autophagy
cell cycle
JNK cascade
heart development
regulation of autophagy
macroautophagy
positive regulation of cell size
negative regulation of extrinsic apoptotic signaling pathway
negative regulation of apoptotic process
biological_process
