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FKBP12 Antibody (PA5-80636) in WB
Western Blot using FKBP12 Polyclonal Antibody (Product # PA5-80636) at 1:500 dilution. Lane A: SH-SY5Y Whole Cell Lysate, Lane B: HL-60 Whole Cell Lysate, Lane C: U937 Whole Cell Lysate. Lysates/proteins at 30 μg per lane. Secondary Goat Anti-Rabbit IgG H&L (DyLight™ 800) at 1:10,000 dilution. Developed using the Odyssey technique. Performed under reducing conditions. Predicted band size: 12 kDa. Observed band size: 12 kDa. (We are unsure of the identity of these extra bands).
产品信息
PA5-80636
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant Human FKBP1A protein (Met1-Glu108)
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Protein A, Antigen affinity chromatography
保存液
PBS
内含物
no preservative
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2787930
产品详细信息
This product is preservative free. It is recommended to add sodium azide to avoid contamination (final concentration 0.05%-0.1%).
This antibody has specificity for Human FKBP1A/FKBP12.
靶标信息
FKBP12 is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. The protein is a cis-trans prolyl isomerase that binds the immunosuppressants FK506 and rapamycin. It interacts with several intracellular signal transduction proteins including type I TGF-beta receptor. It also interacts with multiple intracellular calcium release channels, and coordinates multi-protein complex formation of the tetrameric skeletal muscle ryanodine receptor. In mouse, deletion of this homologous gene causes congenital heart disorder known as noncompaction of left ventricular myocardium.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: 12 kDa FK506-binding protein; 12 kDa FKBP; calstabin 1; Calstabin-1; EC 5.2.1.8; FK506 binding protein 1A, 12kDa; FK506 binding protein12; FK506-binding protein 1; FK506-binding protein 12; FK506-binding protein 1A; FK506-binding protein 1A (12kD); FK506-binding protein, T-cell, 12-kD; FKBP-1A; FKBP12-Exip3; Immunophilin FKBP12; Peptidyl-prolyl cis-trans isomerase FKBP1A; PPIase FKBP1A; protein kinase C inhibitor 2; Rotamase
基因别名: FKBP-12; FKBP-1A; FKBP1; FKBP12; FKBP1A; PKC12; PKCI2; PPIASE
UniProt ID: (Human) P62942
Entrez Gene ID: (Human) 2280
peptidyl-prolyl cis-trans isomerase activity
signal transducer activity
transforming growth factor beta receptor binding
protein binding
macrolide binding
FK506 binding
calcium channel inhibitor activity
type I transforming growth factor beta receptor binding
ion channel binding
SMAD binding
activin binding
chaperone
protein peptidyl-prolyl isomerization
heart morphogenesis
protein folding
'de novo' protein folding
transforming growth factor beta receptor signaling pathway
SMAD protein complex assembly
protein maturation by protein folding
positive regulation of protein ubiquitination
positive regulation of protein binding
negative regulation of protein phosphatase type 2B activity
regulation of protein localization
regulation of activin receptor signaling pathway
protein refolding
T cell activation
positive regulation of I-kappaB kinase/NF-kappaB signaling
extracellular fibril organization
regulation of immune response
negative regulation of release of sequestered calcium ion into cytosol
ventricular cardiac muscle tissue morphogenesis
regulation of ryanodine-sensitive calcium-release channel activity
negative regulation of ryanodine-sensitive calcium-release channel activity
heart trabecula formation
chaperone-mediated protein folding
calcium ion transmembrane transport
regulation of amyloid precursor protein catabolic process
amyloid fibril formation
