Search Thermo Fisher Scientific
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
图: 1 / 4
FLT3 Antibody (PA5-14667) in IHC (P)
Immunohistochemistry analysis of FLT3 in formalin-fixed and paraffin-embedded human cancer tissue. Samples were incubated with FLT3 polyclonal antibody (Product # PA5-14667) which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepato... View More
产品信息
PA5-14667
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
KLH conjugated synthetic peptide between 33-64 amino acids from the N-terminal region of human FLT3 (CD135)
偶联物
形式
Liquid
浓度
1.8 mg/mL
纯化类型
Ammonium sulfate precipitation, Size-exclusion - Dialysis
保存液
PBS, pH 7.4
内含物
0.09% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2104819
靶标信息
FLT3 is a tyrosine protein kinase that is a member of the growth factor receptor tyrosine kinase family. The receptor is activated by binding of the fms-related tyrosine kinase 3 ligand to the extracellular domain, which induces homodimer formation in the plasma membrane leading to autophosphorylation of the receptor. The activated receptor kinase subsequently phosphorylates and activates multiple cytoplasmic effector molecules in pathways involved in apoptosis, proliferation, and differentiation of hematopoietic cells in bone marrow. Mutations that result in the constitutive activation of this receptor result in acute myeloid leukemia and acute lymphoblastic leukemia.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
篇参考文献 (0)
您是否在文献中引用过该产品？请点击下方按钮邮件告知我们。
生物信息学
蛋白别名: CD135; CD135 antigen; fetal liver kinase 2; Fetal liver kinase-2; FL cytokine receptor; FLK-2; FLT-3; Fms-like tyrosine kinase 3; fms-related tyrosine kinase 3; growth factor receptor tyrosine kinase type III; OTTHUMP00000214829; Receptor-type tyrosine-protein kinase FLT3; RP11-153M24.3; Stem cell tyrosine kinase 1; STK-1
基因别名: CD135; FLK-2; FLK2; FLT3; STK1
UniProt ID: (Human) P36888
Entrez Gene ID: (Human) 2322
leukocyte homeostasis
myeloid progenitor cell differentiation
pro-B cell differentiation
transmembrane receptor protein tyrosine kinase signaling pathway
positive regulation of cell proliferation
response to organonitrogen compound
positive regulation of phosphatidylinositol 3-kinase signaling
peptidyl-tyrosine phosphorylation
cytokine-mediated signaling pathway
hemopoiesis
B cell differentiation
organ regeneration
common myeloid progenitor cell proliferation
vascular endothelial growth factor signaling pathway
positive regulation of tyrosine phosphorylation of STAT protein
regulation of apoptotic process
positive regulation of MAP kinase activity
positive regulation of MAPK cascade
positive regulation of phosphatidylinositol 3-kinase activity
lymphocyte proliferation
protein autophosphorylation
cellular response to cytokine stimulus
cellular response to glucocorticoid stimulus
dendritic cell differentiation
