Invitrogen

FMNL2 Polyclonal Antibody

FMNL2 Antibody in Immunocytochemistry (ICC/IF)

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FMNL2 Antibody (PA5-52148) in ICC/IF

Immunofluorecent analysis of FMNL2 in human cell line U-251 MG using FMNL2 Polyclonal Antibody (Product # PA5-52148). Staining shows localization to plasma membrane and cytosol.

FMNL2 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

FMNL2 Antibody in Immunohistochemistry (IHC)

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FMNL2 Antibody — Relative expression in different tissues in IHC: Detection of differential expression levels of FMNL2 demonstrates antibody specificity. Immunohistochemical analysis of FMNL2 using anti-FMNL2 Polyclonal Antibody (Product # PA5-52148), shows significant staining of FMNL2 in human cerebral cortex and shows minimal or weak staining in human liver tissues. The relative expression levels of FMNL2 within each tissue is shown using RNA-Seq. {RE}

产品信息

PA5-52148

应用

建议稀释比

已发表文章

免疫印迹 (WB)

0.04-0.4 µg/mL

免疫组化（石蜡） (IHC (P))

1:50-1:200

免疫细胞化学 (ICC/IF)

0.25-2 µg/mL

产品规格

种属反应

Human

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

Recombinant protein corresponding to Human FMNL2. Recombinant protein control fragment (Product #RP-88596).

查看免疫原

偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

0.1 mg/mL

纯化类型

Antigen affinity chromatography

保存液

PBS, pH 7.2, with 40% glycerol

内含物

0.02% sodium azide

保存条件

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

运输条件

Wet ice

AB_2641681

产品详细信息

Immunogen sequence: ERVEELEENI SHLSEKLQDT ENEAMSKIVE LEKQLMQRNK ELDVVREIYK DANTQVHTLR KMVKEKEEAI QRQSTLEKKI HELEKQGTIK IQKKGDGDIA ILPVVASGTL SMGSEVVAGN SVGP

Highest antigen sequence identity to the following orthologs: Mouse - 94%, Rat - 95%.

靶标信息

Formin-like protein 2 is a cytoplasmic phosphoprotein belonging to the formin homology domain containing protein family and has a DAD (diaphanous autoregulatory domain), FH2 (formin homology 2) domain, and GBD/FH3 (Rho GTPase-binding/formin homology 3) domain. The exact function of FMNL2 is yet to be known but reports suggest that it may have a role in the Wnt signaling pathway. Formin-related proteins are also known to play an important role in morphogenesis, cytokinesis and cell polarity. Several alternatively spliced transcript variants have been described but their full-length nature is not yet determined. It is also known to be associated with a diffuse-type gastric cancer, breast cancer, chondrosarcoma, melanoma, and glioblastoma. FMNL2 might be implicated in polarity control, invasion, migration or metastasis through actin filament nucleation and may be regulated by Rho family GTPase.

仅用于科研。不用于诊断过程。未经明确授权不得转售。