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产品信息
A304-267A
应用
建议稀释比
已发表文章
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Region between residue 329 to 379 of human Farnesyltransferase, CAAX Box, Alpha.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
phosphate/tris citrate, pH 7-8
内含物
0.09% sodium azide
保存条件
4° C
运输条件
Wet ice
产品详细信息
The recommended shelf life for this product is 1 year from date of receipt.
Application Note: For IHC, epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE tissue sections.
靶标信息
FNTA (Farnesyltransferase, CAAX box; alphaCAAX farnesyltransferase alpha subunit, FPTA, FTase-alpha, GGTase-I-alpha, Protein farnesyl transferase/ geranyl geranyl transferase type I alpha subunit(PGGT1A), Ras proteins prenyl transferase alpha, Type I protein geranyl-geranyl transferase alpha subunit) is located locus 8p11 (human). Prenylation is a common intracellular posttranslational protein modification catalyzed by prenyltransferases. The best characterized among these prenyltransferases is the CAAX farnesyl transferase (2. 5. 1. 21), which is alpha-beta heterodimeric enzyme. It catalyzes the attachment of a farnesyl group from farnesyl phosphate to cysteine residues at the fourth position from the C terminus of proteins that end in the CAAX box. FNTA or the alpha subunit of farnesyl transferase is shared by the geranyl-geranyl protein transferases. Apart from transfer of farnesyl and geranyl groups to proteins, FNTA has been proposed to regulate intracellular signaling pathways involving p21ras. Reports have shown that FNTA interacts with TGF-beta and activin-type I receptors.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: CAAX farnesyltransferase subunit alpha; farnesyl-protein transferase alpha-subunit; FTase-alpha; GGTase-I-alpha; Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha; protein prenyltransferase alpha subunit repeat containing 2; Ras proteins prenyltransferase subunit alpha; type I protein geranyl-geranyltransferase alpha subunit; Type I protein geranyl-geranyltransferase subunit alpha
基因别名: FNTA; FPTA; PGGT1A; PTAR2
UniProt ID: (Human) P49354
Entrez Gene ID: (Human) 2339
protein farnesyltransferase activity
protein geranylgeranyltransferase activity
CAAX-protein geranylgeranyltransferase activity
Rab geranylgeranyltransferase activity
protein binding
microtubule binding
acetylcholine receptor regulator activity
receptor tyrosine kinase binding
alpha-tubulin binding
acyltransferase
viral or transposable element protein
cellular component disassembly involved in execution phase of apoptosis
transforming growth factor beta receptor signaling pathway
protein farnesylation
protein geranylgeranylation
regulation of rhodopsin mediated signaling pathway
neurotransmitter receptor metabolic process
skeletal muscle acetylcholine-gated channel clustering
positive regulation of tubulin deacetylation
positive regulation of deacetylase activity
regulation of neurotransmitter receptor activity
