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产品信息
A301-431A
应用
建议稀释比
已发表文章
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Region between residue 175 and 225 of human friend of GATA-1 (zinc finger protein, multitype 1).
偶联物
形式
Liquid
浓度
0.20 mg/mL
纯化类型
Antigen affinity chromatography
保存液
TBS, pH 7.0 to 8.0, with 0.1% BSA
内含物
0.09% sodium azide
保存条件
4° C
运输条件
Wet ice
产品详细信息
The recommended shelf life for this product is 1 year from date of receipt.
Application Note: For IHC, epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE tissue sections.
靶标信息
ZFPM1 is a transcription regulator that plays an essential role in erythroid and megakaryocytic cell differentiation. ZFPM1 is an essential cofactor that acts via the formation of a heterodimer with transcription factors of the GATA family GATA1, GATA2 and GATA3. Such heterodimer can both activate or repress transcriptional activity, depending on the cell and promoter context. The heterodimer formed with GATA proteins is essential to activate expression of genes such as NFE2, ITGA2B, alpha- and beta-globin, while it represses expression of KLF1. ZFPM1 may be involved in regulation of some genes in gonads. ZFPM1 may also be involved in cardiac development, in a non-redundant way with ZFPM2/FOG2.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: FOG-1; friend of GATA 1; Friend of GATA protein 1; friend of GATA-1; Zinc finger protein 89A; Zinc finger protein multitype 1; Zinc finger protein ZFPM1; zinc finger protein, multitype 1
基因别名: FOG; FOG1; ZC2HC11A; ZFN89A; ZFPM1; ZNF408; ZNF89A
UniProt ID: (Human) Q8IX07
Entrez Gene ID: (Human) 161882
RNA polymerase II core promoter sequence-specific DNA binding
transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding
RNA polymerase II transcription factor binding
RNA polymerase II activating transcription factor binding
protein binding
transcription factor binding
metal ion binding
transcription cofactor
negative regulation of transcription from RNA polymerase II promoter
T-helper cell lineage commitment
outflow tract morphogenesis
atrioventricular valve morphogenesis
mitral valve formation
tricuspid valve formation
transcription, DNA-templated
heart development
blood coagulation
regulation of definitive erythrocyte differentiation
erythrocyte differentiation
megakaryocyte differentiation
platelet formation
granulocyte differentiation
negative regulation of protein binding
regulation of chemokine production
embryonic hemopoiesis
megakaryocyte development
positive regulation of interferon-gamma biosynthetic process
negative regulation of interleukin-4 biosynthetic process
negative regulation of fat cell differentiation
cardiac muscle tissue morphogenesis
definitive erythrocyte differentiation
primitive erythrocyte differentiation
negative regulation of mast cell differentiation
ventricular septum morphogenesis
atrial septum morphogenesis
transcriptional activation by promoter-enhancer looping
