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FOXA1 Antibody (MA1-091) in IHC (P)
Immunohistochemistry analysis of FOXA1 showing positive staining in the nucleus and cytoplasm of paraffin-treated Human prostate tissue (right) compared with a negative control in the absence of primary antibody (left). To expose target proteins, antigen retrieval method was performed using 10mM sodium citrate (pH 6.0) microwaved for 8-15 min. Following antigen retrieval, tissues were blocked in 3% H2O2-met... View More
产品信息
MA1-091
产品规格
种属反应
Dog,
Human,
Mouse
宿主/亚型
Mouse
/ IgG
分类
Monoclonal
类型
Antibody
克隆号
3A8
抗原
Recombinant protein expressed in E.coli corresponding to amino acids 1-473 of human FOXA1.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Protein A
保存液
PBS with 1mg/mL BSA, 30% glycerol
内含物
0.05% sodium azide
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2536739
产品详细信息
MA1-091 has been successfully used in Western blot and immunohistochemistry (paraffin) applications with human, mouse and canine samples.
靶标信息
This gene encodes a member of the forkhead class of DNA-binding proteins. These hepatocyte nuclear factors are transcriptional activators for liver-specific transcripts such as albumin and transthyretin, and they also interact with chromatin. Similar family members in mice have roles in the regulation of metabolism and in the differentiation of the pancreas and liver.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Ci-fkh; fkd7; fkh; fork head domain; Forkhead box protein A1; forkhead-7; FoxA4a; hepatocyte nuclear factor 3 alpha (winged helix transcription factor); Hepatocyte nuclear factor 3-alpha; HNF-3-alpha; HNF-3A; HNF3-alpha; HNF3alpha; MGC33105; MGC52590; MGC75967; pintallavis; TCF-3A; tFoxA1; Transcription factor 3A; xfkh1; xfkh2
基因别名: FOXA1; Hnf-3a; HNF3A; Tcf-3a; TCF3A
UniProt ID: (Human) P55317, (Mouse) P35582
Entrez Gene ID: (Dog) 490657, (Human) 3169, (Mouse) 15375
RNA polymerase II transcription factor activity, sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
DNA binding
transcription factor activity, sequence-specific DNA binding
transcription factor binding
protein domain specific binding
sequence-specific DNA binding
transcription regulatory region DNA binding
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
double-stranded DNA binding
negative regulation of transcription from RNA polymerase II promoter
chromatin remodeling
transcription, DNA-templated
regulation of transcription, DNA-templated
transcription from RNA polymerase II promoter
Notch signaling pathway
multicellular organism development
regulation of gene expression
negative regulation of epithelial to mesenchymal transition
chromatin modification
dorsal/ventral neural tube patterning
lung development
response to estradiol
positive regulation of intracellular estrogen receptor signaling pathway
tube morphogenesis
hormone metabolic process
glucose homeostasis
positive regulation of neuron differentiation
positive regulation of smoothened signaling pathway
positive regulation of mitotic cell cycle
positive regulation of transcription from RNA polymerase II promoter
anatomical structure formation involved in morphogenesis
neuron fate specification
positive regulation of sequence-specific DNA binding transcription factor activity
regulation of cell cycle
epithelial tube branching involved in lung morphogenesis
lung epithelial cell differentiation
secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development
epithelial-mesenchymal signaling involved in prostate gland development
prostate gland epithelium morphogenesis
prostate gland stromal morphogenesis
epithelial cell maturation involved in prostate gland development
connective tissue development
covalent chromatin modification
alveolar secondary septum development
dopaminergic neuron differentiation
respiratory basal cell differentiation
positive regulation of cell-cell adhesion mediated by cadherin
